Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056997107> ?p ?o ?g. }
- W2056997107 endingPage "201" @default.
- W2056997107 startingPage "195" @default.
- W2056997107 abstract "Particulate air pollution is associated with respiratory and cardiovascular morbidity and mortality. However, important uncertainties remain in the quantification of extrapulmonary translocation of ultrafine particles into blood circulation. Therefore, the widely used radioiodinated technique was applied to radiolabel polystyrene particles with an average diameter of 56.4 and 202 nm, respectively. The extrapulmonary distribution of these particles (3.7 × 105 Bq/rat) was quantified at 0.5, 2, 24 and 120 h after intratracheal instillation in rats. Moreover, we have taken into account the possible involvement of pulmonary inflammation in this process. Rats which received a single intratracheal instillation of free 125I or a single intravenous injection of labeled ultrafine particles served as control. The results indicated that the pulmonary deposition of radioactivity was almost unchanged for both sizes. Only small amounts of radioactivity (1.64–2.49%) were recovered in blood shortly after administration of both types of particle, in healthy rats. However, the extent of particle translocation into the blood of the ultrafine size following the pretreatment with lipopolysaccharides was significantly higher (from 1.96 ± 0.67 to 4.73 ± 0.31%) compared to larger particles (from 2.19 ± 0.77 to 2.21 ± 0.64%). In conclusion, our findings suggest that only a small fraction of intratracheal-instilled ultrafine particles can pass rapidly into systemic circulation, but this translocation is markedly increased following LPS pretreatment. Thus, pulmonary inflammation seems to play a major role in enhancing the extrapulmonary translocation of particles." @default.
- W2056997107 created "2016-06-24" @default.
- W2056997107 creator A5006816805 @default.
- W2056997107 creator A5013158828 @default.
- W2056997107 creator A5020229477 @default.
- W2056997107 creator A5025368580 @default.
- W2056997107 creator A5032456908 @default.
- W2056997107 creator A5071499932 @default.
- W2056997107 creator A5078431711 @default.
- W2056997107 date "2006-05-01" @default.
- W2056997107 modified "2023-10-11" @default.
- W2056997107 title "Quantification of extrapulmonary translocation of intratracheal-instilled particles in vivo in rats: Effect of lipopolysaccharide" @default.
- W2056997107 cites W1949189465 @default.
- W2056997107 cites W1970513890 @default.
- W2056997107 cites W1970920862 @default.
- W2056997107 cites W1971662370 @default.
- W2056997107 cites W2007450610 @default.
- W2056997107 cites W2008264475 @default.
- W2056997107 cites W2022014262 @default.
- W2056997107 cites W2031145770 @default.
- W2056997107 cites W2035942970 @default.
- W2056997107 cites W2040066643 @default.
- W2056997107 cites W2052416187 @default.
- W2056997107 cites W2059536479 @default.
- W2056997107 cites W2076950685 @default.
- W2056997107 cites W2082391149 @default.
- W2056997107 cites W2101306218 @default.
- W2056997107 cites W2103449823 @default.
- W2056997107 cites W2105068699 @default.
- W2056997107 cites W2114461027 @default.
- W2056997107 cites W2118237085 @default.
- W2056997107 cites W2121681651 @default.
- W2056997107 cites W2125539459 @default.
- W2056997107 cites W2144251181 @default.
- W2056997107 cites W2144679128 @default.
- W2056997107 cites W2146571394 @default.
- W2056997107 cites W2152148584 @default.
- W2056997107 cites W2155118487 @default.
- W2056997107 cites W2413344286 @default.
- W2056997107 cites W4234121831 @default.
- W2056997107 cites W4254240837 @default.
- W2056997107 doi "https://doi.org/10.1016/j.tox.2006.02.016" @default.
- W2056997107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16584826" @default.
- W2056997107 hasPublicationYear "2006" @default.
- W2056997107 type Work @default.
- W2056997107 sameAs 2056997107 @default.
- W2056997107 citedByCount "108" @default.
- W2056997107 countsByYear W20569971072012 @default.
- W2056997107 countsByYear W20569971072013 @default.
- W2056997107 countsByYear W20569971072014 @default.
- W2056997107 countsByYear W20569971072015 @default.
- W2056997107 countsByYear W20569971072016 @default.
- W2056997107 countsByYear W20569971072017 @default.
- W2056997107 countsByYear W20569971072018 @default.
- W2056997107 countsByYear W20569971072019 @default.
- W2056997107 countsByYear W20569971072020 @default.
- W2056997107 countsByYear W20569971072021 @default.
- W2056997107 countsByYear W20569971072022 @default.
- W2056997107 countsByYear W20569971072023 @default.
- W2056997107 crossrefType "journal-article" @default.
- W2056997107 hasAuthorship W2056997107A5006816805 @default.
- W2056997107 hasAuthorship W2056997107A5013158828 @default.
- W2056997107 hasAuthorship W2056997107A5020229477 @default.
- W2056997107 hasAuthorship W2056997107A5025368580 @default.
- W2056997107 hasAuthorship W2056997107A5032456908 @default.
- W2056997107 hasAuthorship W2056997107A5071499932 @default.
- W2056997107 hasAuthorship W2056997107A5078431711 @default.
- W2056997107 hasConcept C104317684 @default.
- W2056997107 hasConcept C126322002 @default.
- W2056997107 hasConcept C138626823 @default.
- W2056997107 hasConcept C142724271 @default.
- W2056997107 hasConcept C147789679 @default.
- W2056997107 hasConcept C150903083 @default.
- W2056997107 hasConcept C185592680 @default.
- W2056997107 hasConcept C187530423 @default.
- W2056997107 hasConcept C203014093 @default.
- W2056997107 hasConcept C207001950 @default.
- W2056997107 hasConcept C2776914184 @default.
- W2056997107 hasConcept C2777714996 @default.
- W2056997107 hasConcept C2777961210 @default.
- W2056997107 hasConcept C2778754761 @default.
- W2056997107 hasConcept C2779078736 @default.
- W2056997107 hasConcept C534529494 @default.
- W2056997107 hasConcept C55493867 @default.
- W2056997107 hasConcept C71924100 @default.
- W2056997107 hasConcept C86803240 @default.
- W2056997107 hasConcept C98274493 @default.
- W2056997107 hasConceptScore W2056997107C104317684 @default.
- W2056997107 hasConceptScore W2056997107C126322002 @default.
- W2056997107 hasConceptScore W2056997107C138626823 @default.
- W2056997107 hasConceptScore W2056997107C142724271 @default.
- W2056997107 hasConceptScore W2056997107C147789679 @default.
- W2056997107 hasConceptScore W2056997107C150903083 @default.
- W2056997107 hasConceptScore W2056997107C185592680 @default.
- W2056997107 hasConceptScore W2056997107C187530423 @default.
- W2056997107 hasConceptScore W2056997107C203014093 @default.
- W2056997107 hasConceptScore W2056997107C207001950 @default.
- W2056997107 hasConceptScore W2056997107C2776914184 @default.