Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057000557> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2057000557 endingPage "181" @default.
- W2057000557 startingPage "170" @default.
- W2057000557 abstract "Primary hepatocellular cancer (HCC) classification systems are based on histopathology and radiology, yet clinical intuition and experience suggest that natural history and disease progression have distinctive clinical features, consistent with a cluster of homogeneous entities within a heterogeneous cohort. We built a rigorous, sequenced, graph-based strategy of network phenotyping analysis (NPA) to combine data smoothing to minimize stochasticity, multivariate analysis to identify ambiguity and prioritize key variables, and k-partite graphs to visualize coherence. In 890 unresectable HCC patients, we selected 13 baseline clinical variables. After rank ordering by survival, we found data structure that exhibited coherence between variables, implying heterogeneity in which survival varied depending on the associated variable profile. The NPA data compression identified five distinctive clinical phenotypes, based only on gender, age, and levels of serum bilirubin, serum alpha-fetoprotein (AFP), and serum gamma glutamyl transpeptidase (GGTP). The phenotypic profiles for gender and age were substantially different. Young, male patients had a low survival, while elderly women had a long survival. Novel clusters included young men, with high AFP levels for their level of bilirubin, as well as women of all ages, with high GGTP values for their level of AFP. The identification of phenotypic groups of HCC may be of value in studies designed to understand their underlying pathophysiology. We conclude that NPA offers a new useful tool in the reclassification of HCC." @default.
- W2057000557 created "2016-06-24" @default.
- W2057000557 creator A5008171752 @default.
- W2057000557 creator A5015850916 @default.
- W2057000557 creator A5032116757 @default.
- W2057000557 date "2010-04-01" @default.
- W2057000557 modified "2023-09-30" @default.
- W2057000557 title "Network-Based Analysis of Survival for Unresectable Hepatocellular Carcinoma" @default.
- W2057000557 cites W1968831951 @default.
- W2057000557 cites W1969971430 @default.
- W2057000557 cites W1987443182 @default.
- W2057000557 cites W1987840736 @default.
- W2057000557 cites W1989727210 @default.
- W2057000557 cites W2034244313 @default.
- W2057000557 cites W2039528484 @default.
- W2057000557 cites W2079254150 @default.
- W2057000557 cites W2081190912 @default.
- W2057000557 cites W2082382028 @default.
- W2057000557 cites W2101937389 @default.
- W2057000557 cites W2114405400 @default.
- W2057000557 cites W2121707384 @default.
- W2057000557 cites W2134338345 @default.
- W2057000557 cites W2136005699 @default.
- W2057000557 cites W2137052325 @default.
- W2057000557 cites W2326082985 @default.
- W2057000557 cites W2411539299 @default.
- W2057000557 doi "https://doi.org/10.1053/j.seminoncol.2010.03.008" @default.
- W2057000557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20494709" @default.
- W2057000557 hasPublicationYear "2010" @default.
- W2057000557 type Work @default.
- W2057000557 sameAs 2057000557 @default.
- W2057000557 citedByCount "14" @default.
- W2057000557 countsByYear W20570005572012 @default.
- W2057000557 countsByYear W20570005572013 @default.
- W2057000557 countsByYear W20570005572014 @default.
- W2057000557 countsByYear W20570005572015 @default.
- W2057000557 countsByYear W20570005572016 @default.
- W2057000557 countsByYear W20570005572017 @default.
- W2057000557 crossrefType "journal-article" @default.
- W2057000557 hasAuthorship W2057000557A5008171752 @default.
- W2057000557 hasAuthorship W2057000557A5015850916 @default.
- W2057000557 hasAuthorship W2057000557A5032116757 @default.
- W2057000557 hasConcept C10515644 @default.
- W2057000557 hasConcept C126322002 @default.
- W2057000557 hasConcept C142724271 @default.
- W2057000557 hasConcept C143998085 @default.
- W2057000557 hasConcept C164465091 @default.
- W2057000557 hasConcept C2778019345 @default.
- W2057000557 hasConcept C38180746 @default.
- W2057000557 hasConcept C71924100 @default.
- W2057000557 hasConcept C72563966 @default.
- W2057000557 hasConceptScore W2057000557C10515644 @default.
- W2057000557 hasConceptScore W2057000557C126322002 @default.
- W2057000557 hasConceptScore W2057000557C142724271 @default.
- W2057000557 hasConceptScore W2057000557C143998085 @default.
- W2057000557 hasConceptScore W2057000557C164465091 @default.
- W2057000557 hasConceptScore W2057000557C2778019345 @default.
- W2057000557 hasConceptScore W2057000557C38180746 @default.
- W2057000557 hasConceptScore W2057000557C71924100 @default.
- W2057000557 hasConceptScore W2057000557C72563966 @default.
- W2057000557 hasIssue "2" @default.
- W2057000557 hasLocation W20570005571 @default.
- W2057000557 hasLocation W20570005572 @default.
- W2057000557 hasOpenAccess W2057000557 @default.
- W2057000557 hasPrimaryLocation W20570005571 @default.
- W2057000557 hasRelatedWork W1972665675 @default.
- W2057000557 hasRelatedWork W1989085620 @default.
- W2057000557 hasRelatedWork W1992278374 @default.
- W2057000557 hasRelatedWork W2055428611 @default.
- W2057000557 hasRelatedWork W2374969042 @default.
- W2057000557 hasRelatedWork W2419775784 @default.
- W2057000557 hasRelatedWork W2518610965 @default.
- W2057000557 hasRelatedWork W2898355850 @default.
- W2057000557 hasRelatedWork W4311847755 @default.
- W2057000557 hasRelatedWork W4361955616 @default.
- W2057000557 hasVolume "37" @default.
- W2057000557 isParatext "false" @default.
- W2057000557 isRetracted "false" @default.
- W2057000557 magId "2057000557" @default.
- W2057000557 workType "article" @default.