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• W2057019209 abstract "A series of new and novel coumarin-6-sulfonamides with a free C4-azidomethyl group have been synthesized as antimicrobials in three steps starting from 7-methyl-4-bromomethylcoumarin 1. The reaction of 1 with chlorosulfonic acid was found to yield the corresponding 6-sulfonylchloride 2, which when treated with sodium azide led to intermediate 3. The title sulfonamides 5a–y were obtained from the reaction of 3 with various aromatic amines 4 in refluxing benzene. The chemical structures of the compounds were elucidated by IR, NMR and LC-MS spectral data. All the synthesized compounds have been screened for their in vitro anti-bacterial and anti-fungal activities. Some of the compounds have been found to be active against both bacterial species at a concentration of 1 μg/mL." @default.
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• W2057019209 date "2010-03-01" @default.
• W2057019209 modified "2023-09-26" @default.
• W2057019209 title "Synthesis and antimicrobial studies on novel sulfonamides containing 4-azidomethyl coumarin" @default.
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• W2057019209 doi "https://doi.org/10.1016/j.ejmech.2009.12.022" @default.
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