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• W2057024061 abstract "Stem and embryonic cells facilitate programming toward multiple daughter cell fates, whereas differentiated cells resist reprogramming and oncogenic transformation. How alterations in the chromatin-based machinery of epigenetic inheritance contribute to these differences remains poorly known. We observed random, heritable changes in GAL4/UAS transgene programming during Drosophila ovarian follicle stem cell differentiation and used them to measure the stage-specific epigenetic stability of gene programming. The frequency of GAL4/UAS reprogramming declines more than 100-fold over the nine divisions comprising this stem cell lineage. Stabilization acts in cis, suggesting that it is chromatin-based, and correlates with increased S phase length. Our results suggest that stem/early progenitor cells cannot accurately transmit nongenetic information to their progeny; full epigenetic competence is acquired only gradually during early differentiation. Modulating epigenetic inheritance may be a critical process controlling transitions between the pleuripotent and differentiated states." @default.
• W2057024061 created "2016-06-24" @default.
• W2057024061 creator A5016264819 @default.
• W2057024061 creator A5030136279 @default.
• W2057024061 date "2010-04-05" @default.
• W2057024061 modified "2023-10-14" @default.
• W2057024061 title "Epigenetic stability increases extensively during <i>Drosophila</i> follicle stem cell differentiation" @default.
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• W2057024061 doi "https://doi.org/10.1073/pnas.1003180107" @default.
• W2057024061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2867689" @default.
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