FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057029785> ?p ?o ?g. }

• W2057029785 endingPage "282" @default.
• W2057029785 startingPage "276" @default.
• W2057029785 abstract "Mecamylamine (MEC), which was initially developed as a ganglionic blocker for the treatment of hypertension has been investigated as a potent antagonist for most types of nicotinic acetylcholine receptors (nAChRs). Most studies of MEC have focused on its inhibitory effects for nAChRs; however its biological uses have recently been expanded to the treatment of psychological disorders accompanying anxiety-related symptoms. Although MEC shows obvious anxiolytic action, there is no clear evidence on its function. In this study, we investigated whether MEC affects brain derived neurotrophic factor (BDNF) expression in vitro and in vivo. MEC increased BDNF expression in differentiated SH-SY5Y cells and the cerebral cortex region of rat brains. To determine if the anxiolytic effect of MEC is associated with BDNF upregulation, the elevated plus maze (EPM) task was conducted in a dexamethasone (DEX)-induced anxiety model. MEC reduced DEX-induced anxiety-like behavior, and increased BDNF expression in the cerebral cortex of rats. These results suggest that the anxiolytic effect of MEC in EPM might be associated with BDNF upregulation in the cerebral cortex region of rats. The therapeutic efficacy of MEC for anxiety might be partly dependent on BDNF modulation." @default.
• W2057029785 created "2016-06-24" @default.
• W2057029785 creator A5058939693 @default.
• W2057029785 creator A5062243563 @default.
• W2057029785 creator A5068162279 @default.
• W2057029785 creator A5069489397 @default.
• W2057029785 creator A5089043298 @default.
• W2057029785 date "2011-07-01" @default.
• W2057029785 modified "2023-10-12" @default.
• W2057029785 title "Mecamylamine attenuates dexamethasone-induced anxiety-like behavior in association with brain derived neurotrophic factor upregulation in rat brains" @default.
• W2057029785 cites W1671833268 @default.
• W2057029785 cites W1967075670 @default.
• W2057029785 cites W1968213313 @default.
• W2057029785 cites W1982165365 @default.
• W2057029785 cites W1999871144 @default.
• W2057029785 cites W2014099101 @default.
• W2057029785 cites W2016105050 @default.
• W2057029785 cites W2023422390 @default.
• W2057029785 cites W2037383099 @default.
• W2057029785 cites W2039598971 @default.
• W2057029785 cites W2041561931 @default.
• W2057029785 cites W2043809720 @default.
• W2057029785 cites W2047670326 @default.
• W2057029785 cites W2047980182 @default.
• W2057029785 cites W2057415261 @default.
• W2057029785 cites W2058684380 @default.
• W2057029785 cites W2059583297 @default.
• W2057029785 cites W2062635423 @default.
• W2057029785 cites W2063533607 @default.
• W2057029785 cites W2066658868 @default.
• W2057029785 cites W2075586399 @default.
• W2057029785 cites W2077857371 @default.
• W2057029785 cites W2085308867 @default.
• W2057029785 cites W2089641935 @default.
• W2057029785 cites W2109523899 @default.
• W2057029785 cites W2140178312 @default.
• W2057029785 cites W2148299837 @default.
• W2057029785 cites W2150640010 @default.
• W2057029785 cites W2156152261 @default.
• W2057029785 cites W2168950597 @default.
• W2057029785 cites W4231001350 @default.
• W2057029785 doi "https://doi.org/10.1016/j.neuropharm.2011.04.013" @default.
• W2057029785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21530554" @default.
• W2057029785 hasPublicationYear "2011" @default.
• W2057029785 type Work @default.
• W2057029785 sameAs 2057029785 @default.
• W2057029785 citedByCount "20" @default.
• W2057029785 countsByYear W20570297852013 @default.
• W2057029785 countsByYear W20570297852014 @default.
• W2057029785 countsByYear W20570297852015 @default.
• W2057029785 countsByYear W20570297852016 @default.
• W2057029785 countsByYear W20570297852017 @default.
• W2057029785 countsByYear W20570297852018 @default.
• W2057029785 countsByYear W20570297852019 @default.
• W2057029785 countsByYear W20570297852020 @default.
• W2057029785 countsByYear W20570297852021 @default.
• W2057029785 countsByYear W20570297852023 @default.
• W2057029785 crossrefType "journal-article" @default.
• W2057029785 hasAuthorship W2057029785A5058939693 @default.
• W2057029785 hasAuthorship W2057029785A5062243563 @default.
• W2057029785 hasAuthorship W2057029785A5068162279 @default.
• W2057029785 hasAuthorship W2057029785A5069489397 @default.
• W2057029785 hasAuthorship W2057029785A5089043298 @default.
• W2057029785 hasConcept C104317684 @default.
• W2057029785 hasConcept C118552586 @default.
• W2057029785 hasConcept C126322002 @default.
• W2057029785 hasConcept C127561419 @default.
• W2057029785 hasConcept C134018914 @default.
• W2057029785 hasConcept C15744967 @default.
• W2057029785 hasConcept C160539049 @default.
• W2057029785 hasConcept C169760540 @default.
• W2057029785 hasConcept C170493617 @default.
• W2057029785 hasConcept C173586616 @default.
• W2057029785 hasConcept C185592680 @default.
• W2057029785 hasConcept C2776880047 @default.
• W2057029785 hasConcept C2776885963 @default.
• W2057029785 hasConcept C2777765862 @default.
• W2057029785 hasConcept C2778790584 @default.
• W2057029785 hasConcept C55493867 @default.
• W2057029785 hasConcept C558461103 @default.
• W2057029785 hasConcept C71924100 @default.
• W2057029785 hasConceptScore W2057029785C104317684 @default.
• W2057029785 hasConceptScore W2057029785C118552586 @default.
• W2057029785 hasConceptScore W2057029785C126322002 @default.
• W2057029785 hasConceptScore W2057029785C127561419 @default.
• W2057029785 hasConceptScore W2057029785C134018914 @default.
• W2057029785 hasConceptScore W2057029785C15744967 @default.
• W2057029785 hasConceptScore W2057029785C160539049 @default.
• W2057029785 hasConceptScore W2057029785C169760540 @default.
• W2057029785 hasConceptScore W2057029785C170493617 @default.
• W2057029785 hasConceptScore W2057029785C173586616 @default.
• W2057029785 hasConceptScore W2057029785C185592680 @default.
• W2057029785 hasConceptScore W2057029785C2776880047 @default.
• W2057029785 hasConceptScore W2057029785C2776885963 @default.
• W2057029785 hasConceptScore W2057029785C2777765862 @default.
• W2057029785 hasConceptScore W2057029785C2778790584 @default.
• W2057029785 hasConceptScore W2057029785C55493867 @default.
• W2057029785 hasConceptScore W2057029785C558461103 @default.

• next