Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057029903> ?p ?o ?g. }
- W2057029903 endingPage "1096" @default.
- W2057029903 startingPage "1084" @default.
- W2057029903 abstract "Synaptosome-associated protein of 25 kDa (SNAP25) is a component of the fusion complex that mediates synaptic vesicle exocytosis, regulates calcium dynamics and neuronal plasticity. Despite its crucial role in vesicle release, SNAP25 is not distributed homogenously within the brain. It seems to be virtually absent in mature inhibitory terminals and is observed in a subtype of excitatory neurons defined by the expression of vesicular glutamate transporter 1 (VGluT1). Since a complementary distribution of VGluT1 and VGluT2 in excitatory synapses is correlated with different probabilities of release (Pr), we evaluated whether SNAP25 localization is associated with specific synaptic properties. In the cerebellum, climbing fiber (CF) and parallel fiber (PF) inputs, which impinge onto the same Purkinje cell (PC), have very different functional properties. In the cerebellum of adult rats, using confocal and electron microscopy, we observed that VGluT2-positive CFs, characterized by a high Pr, only weakly express SNAP25, while VGluT1-positive PFs that show a low Pr abundantly express SNAP25. Moreover, SNAP25 was less profuse in the VGluT2-positive rosettes of mossy fibers (MFs) and was almost absent in inhibitory terminals. We extended our analysis to the SNAP23 homolog; this is expressed at different levels in both gamma-aminobutyric acid-containing terminals (GABAergic) and glutamatergic terminals of the cerebellar cortex. In conclusion, the preferential localization of SNAP25 in specific synaptic boutons suggests a correlation between SNAP25 and the Pr. This evidence supports the hypothesis that SNAP25 has a modulatory role in shaping synaptic responses." @default.
- W2057029903 created "2016-06-24" @default.
- W2057029903 creator A5008101621 @default.
- W2057029903 creator A5008665410 @default.
- W2057029903 creator A5022437745 @default.
- W2057029903 creator A5032523995 @default.
- W2057029903 creator A5046666141 @default.
- W2057029903 creator A5072767288 @default.
- W2057029903 creator A5079931065 @default.
- W2057029903 date "2009-12-01" @default.
- W2057029903 modified "2023-10-17" @default.
- W2057029903 title "Distribution of the SNAP25 and SNAP23 synaptosomal-associated protein isoforms in rat cerebellar cortex" @default.
- W2057029903 cites W138403972 @default.
- W2057029903 cites W1520187505 @default.
- W2057029903 cites W1601354097 @default.
- W2057029903 cites W1733290480 @default.
- W2057029903 cites W1788084167 @default.
- W2057029903 cites W187316316 @default.
- W2057029903 cites W1967517418 @default.
- W2057029903 cites W1969272808 @default.
- W2057029903 cites W1972529694 @default.
- W2057029903 cites W1974056290 @default.
- W2057029903 cites W1976665624 @default.
- W2057029903 cites W1977714149 @default.
- W2057029903 cites W1980053286 @default.
- W2057029903 cites W1981363187 @default.
- W2057029903 cites W1982362264 @default.
- W2057029903 cites W1983897795 @default.
- W2057029903 cites W1984606410 @default.
- W2057029903 cites W1990522517 @default.
- W2057029903 cites W1995283271 @default.
- W2057029903 cites W1996063179 @default.
- W2057029903 cites W1996618398 @default.
- W2057029903 cites W1998995979 @default.
- W2057029903 cites W2000302106 @default.
- W2057029903 cites W2002338753 @default.
- W2057029903 cites W2007239691 @default.
- W2057029903 cites W2009573901 @default.
- W2057029903 cites W2011435140 @default.
- W2057029903 cites W2018576843 @default.
- W2057029903 cites W2020008894 @default.
- W2057029903 cites W2022050193 @default.
- W2057029903 cites W2023695373 @default.
- W2057029903 cites W2028474222 @default.
- W2057029903 cites W2029553343 @default.
- W2057029903 cites W2037718442 @default.
- W2057029903 cites W2037841295 @default.
- W2057029903 cites W2041917900 @default.
- W2057029903 cites W2044162798 @default.
- W2057029903 cites W2049232195 @default.
- W2057029903 cites W2050123488 @default.
- W2057029903 cites W2051856772 @default.
- W2057029903 cites W2055137643 @default.
- W2057029903 cites W2063771096 @default.
- W2057029903 cites W2063958606 @default.
- W2057029903 cites W2065723295 @default.
- W2057029903 cites W2067990755 @default.
- W2057029903 cites W2071483088 @default.
- W2057029903 cites W207575143 @default.
- W2057029903 cites W2076069761 @default.
- W2057029903 cites W2077451533 @default.
- W2057029903 cites W2078752074 @default.
- W2057029903 cites W2080199415 @default.
- W2057029903 cites W2081549844 @default.
- W2057029903 cites W2085502415 @default.
- W2057029903 cites W2085680244 @default.
- W2057029903 cites W2105722661 @default.
- W2057029903 cites W2106080070 @default.
- W2057029903 cites W2112227347 @default.
- W2057029903 cites W2113574370 @default.
- W2057029903 cites W2123065833 @default.
- W2057029903 cites W2129344306 @default.
- W2057029903 cites W2132331561 @default.
- W2057029903 cites W2134554383 @default.
- W2057029903 cites W2138689772 @default.
- W2057029903 cites W2145168338 @default.
- W2057029903 cites W2152687237 @default.
- W2057029903 cites W2158177370 @default.
- W2057029903 cites W2161993137 @default.
- W2057029903 cites W2162740393 @default.
- W2057029903 cites W2163618989 @default.
- W2057029903 cites W2171969603 @default.
- W2057029903 cites W2173578956 @default.
- W2057029903 cites W9573170 @default.
- W2057029903 doi "https://doi.org/10.1016/j.neuroscience.2009.08.067" @default.
- W2057029903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19735702" @default.
- W2057029903 hasPublicationYear "2009" @default.
- W2057029903 type Work @default.
- W2057029903 sameAs 2057029903 @default.
- W2057029903 citedByCount "25" @default.
- W2057029903 countsByYear W20570299032012 @default.
- W2057029903 countsByYear W20570299032013 @default.
- W2057029903 countsByYear W20570299032014 @default.
- W2057029903 countsByYear W20570299032015 @default.
- W2057029903 countsByYear W20570299032016 @default.
- W2057029903 countsByYear W20570299032017 @default.
- W2057029903 countsByYear W20570299032018 @default.
- W2057029903 countsByYear W20570299032019 @default.