FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057034023> ?p ?o ?g. }

• W2057034023 endingPage "494" @default.
• W2057034023 startingPage "485" @default.
• W2057034023 abstract "Interleukin-6 mediates host defense and cell survival mainly through the activation of the transcription factor STAT3 via the glycoprotein gp130, a shared signal-transducing receptor for several IL-6-type cytokines. We have reported that the cardiotrophic parasite Trypanosoma cruzi protects murine cardiomyocytes from apoptosis. In agreement, an intense induction of the anti-apoptotic factor Bcl-2 is found in cardiac fibers during the acute phase of infection, establishing a higher threshold against apoptosis. We report here that inactive cruzipain, the main cysteine protease secreted by the parasite, specifically triggered TLR2 and the subsequent release of IL-6, which acted as an essential anti-apoptotic factor for cardiomyocyte cultures. Although comparable IL-6 levels were found under active cruzipain stimulation, starved cardiac cell monolayers could not be rescued from apoptosis. Moreover, cardiomyocytes treated with active cruzipain completely abrogated the STAT3 phosphorylation and nuclear translocation induced by recombinant IL-6. This inhibition was also observed on splenocytes, but it was reverted when the enzyme was complexed with chagasin, a parasite cysteine protease inhibitor. Furthermore, the inhibition of IL-6-induced p-STAT3 was evidenced in spleen cells stimulated with pre-activated supernatants derived from trypomastigotes. To account for these observations, we found that cruzipain enzymatically cleaved recombinant gp130 ectodomain, and induced the release of membrane-distal N-terminal domain of this receptor on human peripheral blood mononuclear cells. These results demonstrate, for the first time, that the parasite may modify the IL-6-induced response through the modulation of its cysteine protease activity, suggesting that specific inhibitors may help to improve the immune cell activation and cardioprotective effects." @default.
• W2057034023 created "2016-06-24" @default.
• W2057034023 creator A5014505825 @default.
• W2057034023 creator A5021690095 @default.
• W2057034023 creator A5022619388 @default.
• W2057034023 creator A5023967526 @default.
• W2057034023 creator A5030476976 @default.
• W2057034023 creator A5033069942 @default.
• W2057034023 creator A5058636905 @default.
• W2057034023 creator A5074901091 @default.
• W2057034023 date "2013-03-01" @default.
• W2057034023 modified "2023-10-12" @default.
• W2057034023 title "Trypanosoma cruzi, the causative agent of Chagas disease, modulates interleukin-6-induced STAT3 phosphorylation via gp130 cleavage in different host cells" @default.
• W2057034023 cites W1489742081 @default.
• W2057034023 cites W1506297185 @default.
• W2057034023 cites W1573665547 @default.
• W2057034023 cites W1965633191 @default.
• W2057034023 cites W1970182517 @default.
• W2057034023 cites W1973983858 @default.
• W2057034023 cites W1974691095 @default.
• W2057034023 cites W1988917700 @default.
• W2057034023 cites W1993511695 @default.
• W2057034023 cites W1996983996 @default.
• W2057034023 cites W1997432386 @default.
• W2057034023 cites W2005287646 @default.
• W2057034023 cites W2008954387 @default.
• W2057034023 cites W2026679488 @default.
• W2057034023 cites W2028241146 @default.
• W2057034023 cites W2063407488 @default.
• W2057034023 cites W2095916917 @default.
• W2057034023 cites W2111687357 @default.
• W2057034023 cites W2111894384 @default.
• W2057034023 cites W2113774618 @default.
• W2057034023 cites W2115806010 @default.
• W2057034023 cites W2119120508 @default.
• W2057034023 cites W2120472021 @default.
• W2057034023 cites W2125543544 @default.
• W2057034023 cites W2148418046 @default.
• W2057034023 cites W2156962712 @default.
• W2057034023 cites W2162535796 @default.
• W2057034023 cites W2165199797 @default.
• W2057034023 cites W2165309166 @default.
• W2057034023 cites W2186964941 @default.
• W2057034023 doi "https://doi.org/10.1016/j.bbadis.2012.12.003" @default.
• W2057034023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23253440" @default.
• W2057034023 hasPublicationYear "2013" @default.
• W2057034023 type Work @default.
• W2057034023 sameAs 2057034023 @default.
• W2057034023 citedByCount "18" @default.
• W2057034023 countsByYear W20570340232016 @default.
• W2057034023 countsByYear W20570340232017 @default.
• W2057034023 countsByYear W20570340232018 @default.
• W2057034023 countsByYear W20570340232019 @default.
• W2057034023 countsByYear W20570340232020 @default.
• W2057034023 countsByYear W20570340232021 @default.
• W2057034023 countsByYear W20570340232022 @default.
• W2057034023 crossrefType "journal-article" @default.
• W2057034023 hasAuthorship W2057034023A5014505825 @default.
• W2057034023 hasAuthorship W2057034023A5021690095 @default.
• W2057034023 hasAuthorship W2057034023A5022619388 @default.
• W2057034023 hasAuthorship W2057034023A5023967526 @default.
• W2057034023 hasAuthorship W2057034023A5030476976 @default.
• W2057034023 hasAuthorship W2057034023A5033069942 @default.
• W2057034023 hasAuthorship W2057034023A5058636905 @default.
• W2057034023 hasAuthorship W2057034023A5074901091 @default.
• W2057034023 hasBestOaLocation W20570340231 @default.
• W2057034023 hasConcept C136764020 @default.
• W2057034023 hasConcept C139964883 @default.
• W2057034023 hasConcept C153911025 @default.
• W2057034023 hasConcept C181199279 @default.
• W2057034023 hasConcept C190283241 @default.
• W2057034023 hasConcept C2776714187 @default.
• W2057034023 hasConcept C2777283782 @default.
• W2057034023 hasConcept C2777625466 @default.
• W2057034023 hasConcept C31573885 @default.
• W2057034023 hasConcept C41008148 @default.
• W2057034023 hasConcept C55493867 @default.
• W2057034023 hasConcept C71928629 @default.
• W2057034023 hasConcept C86803240 @default.
• W2057034023 hasConcept C95444343 @default.
• W2057034023 hasConceptScore W2057034023C136764020 @default.
• W2057034023 hasConceptScore W2057034023C139964883 @default.
• W2057034023 hasConceptScore W2057034023C153911025 @default.
• W2057034023 hasConceptScore W2057034023C181199279 @default.
• W2057034023 hasConceptScore W2057034023C190283241 @default.
• W2057034023 hasConceptScore W2057034023C2776714187 @default.
• W2057034023 hasConceptScore W2057034023C2777283782 @default.
• W2057034023 hasConceptScore W2057034023C2777625466 @default.
• W2057034023 hasConceptScore W2057034023C31573885 @default.
• W2057034023 hasConceptScore W2057034023C41008148 @default.
• W2057034023 hasConceptScore W2057034023C55493867 @default.
• W2057034023 hasConceptScore W2057034023C71928629 @default.
• W2057034023 hasConceptScore W2057034023C86803240 @default.
• W2057034023 hasConceptScore W2057034023C95444343 @default.
• W2057034023 hasFunder F4320311827 @default.
• W2057034023 hasFunder F4320321594 @default.
• W2057034023 hasIssue "3" @default.
• W2057034023 hasLocation W20570340231 @default.

• next