FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057046064> ?p ?o ?g. }

• W2057046064 endingPage "e0124134" @default.
• W2057046064 startingPage "e0124134" @default.
• W2057046064 abstract "Tuberculosis (TB) is among the leading causes of morbidity and mortality. The causative agent, Mycobacterium tuberculosis (Mtb), has evolved virulent factors for entry, survival, multiplication and immune evasion. Rv2031 (also called alpha crystallin, hspX, 16-kDa antigen), one of the most immunogenic latency antigens, is believed to play a key role in long-term viability of Mtb. Here, we report the dynamics of pro-inflammatory (IFN-γ, TNF-α) and anti-inflammatory (IL-10) cytokines against Rv2031 using whole blood assay in human cohorts in a TB endemic setting. Cytokine responses to ESAT-6-CFP-10 were also measured for comparison. Blood samples were collected from smear positive pulmonary TB patients and their contacts at baseline, 6 and 12 months, and from community controls at entry. At baseline, 54.4% of controls and 73.2% of contacts were QFT-GIT test positive. Baseline IFN-γ, TNF-α and IL-10 responses to Rv2031 were significantly higher in controls compared to contacts and untreated patients (p<0.001). Furthermore, untreated patients had significantly higher TNF-α and IL-10 responses to Rv2031 compared to contacts (p<0.001). In contacts and treated patients, IFN-γ, TNF-α and IL-10 responses to Rv2031 significantly increased over 12 months (p<0.0001) and became comparable with the corresponding levels in controls. There was a positive and significant correlation between Rv2031 and ESAT-6-CFP-10 specific cytokine responses in each study group. The fact that the levels of IFN-γ, TNF-α and IL-10 against Rv2031 were highest during latent TB infection may indicate their potential as markers of protection against TB. Taken together, the findings of this study suggest the potential of IFN-γ, TNF-α and IL-10 against Rv2031 as biomarkers of the host response to Mtb during convalescence from, and the absence of, active tuberculosis." @default.
• W2057046064 created "2016-06-24" @default.
• W2057046064 creator A5004201118 @default.
• W2057046064 creator A5009298989 @default.
• W2057046064 creator A5009359329 @default.
• W2057046064 creator A5017800449 @default.
• W2057046064 creator A5020567778 @default.
• W2057046064 creator A5039624437 @default.
• W2057046064 creator A5056020137 @default.
• W2057046064 creator A5090962478 @default.
• W2057046064 date "2015-04-21" @default.
• W2057046064 modified "2023-09-23" @default.
• W2057046064 title "Pro- and Anti-Inflammatory Cytokines against Rv2031 Are Elevated during Latent Tuberculosis: A Study in Cohorts of Tuberculosis Patients, Household Contacts and Community Controls in an Endemic Setting" @default.
• W2057046064 cites W1490010577 @default.
• W2057046064 cites W1543888238 @default.
• W2057046064 cites W1851138068 @default.
• W2057046064 cites W1977868250 @default.
• W2057046064 cites W1984685566 @default.
• W2057046064 cites W1995560626 @default.
• W2057046064 cites W2002656284 @default.
• W2057046064 cites W2019378289 @default.
• W2057046064 cites W2019993409 @default.
• W2057046064 cites W2023061016 @default.
• W2057046064 cites W2024145757 @default.
• W2057046064 cites W2033805483 @default.
• W2057046064 cites W2042971327 @default.
• W2057046064 cites W2056246244 @default.
• W2057046064 cites W2058153241 @default.
• W2057046064 cites W2075477269 @default.
• W2057046064 cites W2098984708 @default.
• W2057046064 cites W2108124040 @default.
• W2057046064 cites W2120696671 @default.
• W2057046064 cites W2131947327 @default.
• W2057046064 cites W2147077255 @default.
• W2057046064 cites W2166036585 @default.
• W2057046064 cites W2170593843 @default.
• W2057046064 cites W2414547019 @default.
• W2057046064 cites W44081236 @default.
• W2057046064 doi "https://doi.org/10.1371/journal.pone.0124134" @default.
• W2057046064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4405476" @default.
• W2057046064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25897840" @default.
• W2057046064 hasPublicationYear "2015" @default.
• W2057046064 type Work @default.
• W2057046064 sameAs 2057046064 @default.
• W2057046064 citedByCount "29" @default.
• W2057046064 countsByYear W20570460642015 @default.
• W2057046064 countsByYear W20570460642016 @default.
• W2057046064 countsByYear W20570460642017 @default.
• W2057046064 countsByYear W20570460642018 @default.
• W2057046064 countsByYear W20570460642019 @default.
• W2057046064 countsByYear W20570460642020 @default.
• W2057046064 countsByYear W20570460642021 @default.
• W2057046064 countsByYear W20570460642022 @default.
• W2057046064 countsByYear W20570460642023 @default.
• W2057046064 crossrefType "journal-article" @default.
• W2057046064 hasAuthorship W2057046064A5004201118 @default.
• W2057046064 hasAuthorship W2057046064A5009298989 @default.
• W2057046064 hasAuthorship W2057046064A5009359329 @default.
• W2057046064 hasAuthorship W2057046064A5017800449 @default.
• W2057046064 hasAuthorship W2057046064A5020567778 @default.
• W2057046064 hasAuthorship W2057046064A5039624437 @default.
• W2057046064 hasAuthorship W2057046064A5056020137 @default.
• W2057046064 hasAuthorship W2057046064A5090962478 @default.
• W2057046064 hasBestOaLocation W20570460641 @default.
• W2057046064 hasConcept C142724271 @default.
• W2057046064 hasConcept C147483822 @default.
• W2057046064 hasConcept C17991360 @default.
• W2057046064 hasConcept C187316574 @default.
• W2057046064 hasConcept C203014093 @default.
• W2057046064 hasConcept C2777975735 @default.
• W2057046064 hasConcept C2778690821 @default.
• W2057046064 hasConcept C2779806340 @default.
• W2057046064 hasConcept C2780841837 @default.
• W2057046064 hasConcept C2781069245 @default.
• W2057046064 hasConcept C71924100 @default.
• W2057046064 hasConcept C8891405 @default.
• W2057046064 hasConceptScore W2057046064C142724271 @default.
• W2057046064 hasConceptScore W2057046064C147483822 @default.
• W2057046064 hasConceptScore W2057046064C17991360 @default.
• W2057046064 hasConceptScore W2057046064C187316574 @default.
• W2057046064 hasConceptScore W2057046064C203014093 @default.
• W2057046064 hasConceptScore W2057046064C2777975735 @default.
• W2057046064 hasConceptScore W2057046064C2778690821 @default.
• W2057046064 hasConceptScore W2057046064C2779806340 @default.
• W2057046064 hasConceptScore W2057046064C2780841837 @default.
• W2057046064 hasConceptScore W2057046064C2781069245 @default.
• W2057046064 hasConceptScore W2057046064C71924100 @default.
• W2057046064 hasConceptScore W2057046064C8891405 @default.
• W2057046064 hasIssue "4" @default.
• W2057046064 hasLocation W20570460641 @default.
• W2057046064 hasLocation W20570460642 @default.
• W2057046064 hasLocation W20570460643 @default.
• W2057046064 hasLocation W20570460644 @default.
• W2057046064 hasLocation W20570460645 @default.
• W2057046064 hasOpenAccess W2057046064 @default.
• W2057046064 hasPrimaryLocation W20570460641 @default.
• W2057046064 hasRelatedWork W13777425 @default.
• W2057046064 hasRelatedWork W1593447497 @default.

• next