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• W2057053269 abstract "The O-2A progenitor cell first described from the rat optic nerve is a bipotential precursor of oligodendrocytes and type 2 astrocytes. Each cell expresses specific markers that distinguish them as unique cell types. O-2A progenitors cultured in high serum preferentially differntiate into type 2 astrocytes and when exposed to defined medium or low serum develop along the oligodendrocyte lineage. We analyzed the gap junction gene expression of type 2 astrocytes to determine if they are coupled to form a syncytium, like their type 1 astrocyte counterparts. Dye coupling experiments demonstrated that cortical type 2 astrocytes are not coupled, while type 1 astrocytes in the same culture dish are highly coupled. Immunocytochemistry revealed the presence of Cx43 in type 1 astrocytes but we could not detect Cx26, 32, or 43 protein in type 2 astrocytes. In situ hybridization did not detect mRNA for any of the three connexin genes in type 2 astrocytes. These data demonstrate that type 2 astrocytes do not express the major gap junction genes found in the central nervous system. The precise function of type 2 astrocytes is not known but the lack of gap junction genes expression suggests that their functions are different from the spatial buffering capacity of type 1 astrocytes." @default.
• W2057053269 created "2016-06-24" @default.
• W2057053269 creator A5060119478 @default.
• W2057053269 creator A5065731197 @default.
• W2057053269 date "1994-09-01" @default.
• W2057053269 modified "2023-09-23" @default.
• W2057053269 title "Cortical type 2 astrocytes are not dye coupled nor do they express the major gap junction genes found in the central nervous system" @default.
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• W2057053269 doi "https://doi.org/10.1002/glia.440120104" @default.
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