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• W2057060116 abstract "Adrenaline and insulin are the major hormones regulating glycogen metabolism in skeletal muscle. We have investigated the effects of these hormones on the rate-limiting enzymes of glycogen degradation and synthesis (phosphorylase and glycogen synthase respectively) in GM−/− mice homozygous for a null allele of the major skeletal muscle glycogen targeting subunit (GM) of protein phosphatase 1 (PP1). Hyperphosphorylation of Ser14 in phosphorylase, and Ser7, Ser640 and Ser640/644 of GS, in the skeletal muscle of GM−/− mice compared with GM+/+ mice indicates that the PP1-GM complex is the major phosphatase that dephosphorylates these sites in vivo. Adrenaline caused a 2.4-fold increase in the phosphorylase (−/+AMP) activity ratio in the skeletal muscle of control mice compared to a 1.4 fold increase in GM−/− mice. Adrenaline also elicited a 67% decrease in the GS (−/+G6P) activity ratio in control mice but only a small decrease in the skeletal muscle of GM−/− mice indicating that GM is required for the full response of phosphorylase and GS to adrenaline. PP1-GM activity and the amount of PP1 bound to GM decreased 40% and 45% respectively, in response to adrenaline in control mice. The data support a model in which adrenaline stimulates phosphorylation of phosphorylase Ser14 and GS Ser7 in GM+/+ mice by both kinase activation and PP1-GM inhibition and the phosphorylation of GS Ser640 and Ser640/644 by PP1-GM inhibition alone. Insulin decreased the phosphorylation of GS Ser640 and Ser640/644 and stimulated the GS (−/+G6P) activity ratio by ∼ 2-fold in the skeletal muscle of either GM−/− and or control mice, but the low basal and insulin stimulated GS activity ratios in GM−/− mice indicate that PP1-GM is essential for maintaining normal basal and maximum insulin stimulated GS activity ratios in vivo." @default.
• W2057060116 created "2016-06-24" @default.
• W2057060116 creator A5002671502 @default.
• W2057060116 creator A5020249557 @default.
• W2057060116 date "2007-05-01" @default.
• W2057060116 modified "2023-09-27" @default.
• W2057060116 title "The skeletal muscle-specific glycogen-targeted protein phosphatase 1 plays a major role in the regulation of glycogen metabolism by adrenaline in vivo" @default.
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• W2057060116 doi "https://doi.org/10.1016/j.cellsig.2006.11.013" @default.
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