FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057065862> ?p ?o ?g. }

• W2057065862 abstract "Regulation of gene expression plays a pivotal role in cellular functions. However, understanding the dynamics of transcription remains a challenging task. A host of computational approaches have been developed to identify regulatory motifs, mainly based on the recognition of DNA sequences for transcription factor binding sites. Recent integration of additional data from genomic analyses or phylogenetic footprinting has significantly improved these methods. Here, we propose a different approach based on the compilation of Simple Shared Motifs (SSM), groups of sequences defined by their length and similarity and present in conserved sequences of gene promoters. We developed an original algorithm to search and count SSM in pairs of genes. An exceptional number of SSM is considered as a common regulatory pattern. The SSM approach is applied to a sample set of genes and validated using functional gene-set enrichment analyses. We demonstrate that the SSM approach selects genes that are over-represented in specific biological categories (Ontology and Pathways) and are enriched in co-expressed genes. Finally we show that genes co-expressed in the same tissue or involved in the same biological pathway have increased SSM values. Using unbiased clustering of genes, Simple Shared Motifs analysis constitutes an original contribution to provide a clearer definition of expression networks." @default.
• W2057065862 created "2016-06-24" @default.
• W2057065862 creator A5005146709 @default.
• W2057065862 creator A5012152238 @default.
• W2057065862 creator A5046388663 @default.
• W2057065862 creator A5059120182 @default.
• W2057065862 date "2011-09-12" @default.
• W2057065862 modified "2023-10-06" @default.
• W2057065862 title "Simple Shared Motifs (SSM) in conserved region of promoters: a new approach to identify co-regulation patterns" @default.
• W2057065862 cites W1982151339 @default.
• W2057065862 cites W1988393300 @default.
• W2057065862 cites W1997421058 @default.
• W2057065862 cites W2003967338 @default.
• W2057065862 cites W2015502807 @default.
• W2057065862 cites W2020016375 @default.
• W2057065862 cites W2034784092 @default.
• W2057065862 cites W2041726559 @default.
• W2057065862 cites W2057918976 @default.
• W2057065862 cites W2062872358 @default.
• W2057065862 cites W2064879068 @default.
• W2057065862 cites W2065095433 @default.
• W2057065862 cites W2084620487 @default.
• W2057065862 cites W2087892194 @default.
• W2057065862 cites W2095617232 @default.
• W2057065862 cites W2098412979 @default.
• W2057065862 cites W2103017472 @default.
• W2057065862 cites W2105877777 @default.
• W2057065862 cites W2106848313 @default.
• W2057065862 cites W2106882534 @default.
• W2057065862 cites W2107768450 @default.
• W2057065862 cites W2116495755 @default.
• W2057065862 cites W2119104284 @default.
• W2057065862 cites W2123106337 @default.
• W2057065862 cites W2128091972 @default.
• W2057065862 cites W2129061533 @default.
• W2057065862 cites W2130410032 @default.
• W2057065862 cites W2131706188 @default.
• W2057065862 cites W2136726922 @default.
• W2057065862 cites W2137144878 @default.
• W2057065862 cites W2138255346 @default.
• W2057065862 cites W2141395444 @default.
• W2057065862 cites W2141408320 @default.
• W2057065862 cites W2145091349 @default.
• W2057065862 cites W2147154551 @default.
• W2057065862 cites W2149080058 @default.
• W2057065862 cites W2149909623 @default.
• W2057065862 cites W2150612336 @default.
• W2057065862 cites W2161732139 @default.
• W2057065862 cites W2161888246 @default.
• W2057065862 cites W2162836426 @default.
• W2057065862 cites W2169056802 @default.
• W2057065862 cites W2342204193 @default.
• W2057065862 cites W4211018930 @default.
• W2057065862 cites W4294216483 @default.
• W2057065862 doi "https://doi.org/10.1186/1471-2105-12-365" @default.
• W2057065862 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3215511" @default.
• W2057065862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21910886" @default.
• W2057065862 hasPublicationYear "2011" @default.
• W2057065862 type Work @default.
• W2057065862 sameAs 2057065862 @default.
• W2057065862 citedByCount "2" @default.
• W2057065862 countsByYear W20570658622013 @default.
• W2057065862 countsByYear W20570658622020 @default.
• W2057065862 crossrefType "journal-article" @default.
• W2057065862 hasAuthorship W2057065862A5005146709 @default.
• W2057065862 hasAuthorship W2057065862A5012152238 @default.
• W2057065862 hasAuthorship W2057065862A5046388663 @default.
• W2057065862 hasAuthorship W2057065862A5059120182 @default.
• W2057065862 hasBestOaLocation W20570658621 @default.
• W2057065862 hasConcept C101762097 @default.
• W2057065862 hasConcept C104317684 @default.
• W2057065862 hasConcept C150194340 @default.
• W2057065862 hasConcept C193252679 @default.
• W2057065862 hasConcept C199216141 @default.
• W2057065862 hasConcept C21592294 @default.
• W2057065862 hasConcept C3017666073 @default.
• W2057065862 hasConcept C3662595 @default.
• W2057065862 hasConcept C54355233 @default.
• W2057065862 hasConcept C67339327 @default.
• W2057065862 hasConcept C70721500 @default.
• W2057065862 hasConcept C86339819 @default.
• W2057065862 hasConcept C86803240 @default.
• W2057065862 hasConcept C95371953 @default.
• W2057065862 hasConceptScore W2057065862C101762097 @default.
• W2057065862 hasConceptScore W2057065862C104317684 @default.
• W2057065862 hasConceptScore W2057065862C150194340 @default.
• W2057065862 hasConceptScore W2057065862C193252679 @default.
• W2057065862 hasConceptScore W2057065862C199216141 @default.
• W2057065862 hasConceptScore W2057065862C21592294 @default.
• W2057065862 hasConceptScore W2057065862C3017666073 @default.
• W2057065862 hasConceptScore W2057065862C3662595 @default.
• W2057065862 hasConceptScore W2057065862C54355233 @default.
• W2057065862 hasConceptScore W2057065862C67339327 @default.
• W2057065862 hasConceptScore W2057065862C70721500 @default.
• W2057065862 hasConceptScore W2057065862C86339819 @default.
• W2057065862 hasConceptScore W2057065862C86803240 @default.
• W2057065862 hasConceptScore W2057065862C95371953 @default.
• W2057065862 hasIssue "1" @default.
• W2057065862 hasLocation W20570658621 @default.
• W2057065862 hasLocation W20570658622 @default.

• next