FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057074966> ?p ?o ?g. }

• W2057074966 endingPage "1669" @default.
• W2057074966 startingPage "1658" @default.
• W2057074966 abstract "Elevation in cytoplasmic free Ca2+ concentration ([Ca2+]i) is a common mechanism in signaling events. An increased [Ca2+]i induced by GH, has been observed in relation to different cellular events. Little is known about the mechanism underlying the GH effect on Ca2+ handling. We have studied the molecular mechanisms underlying GH-induced rise in [Ca2+]i in BRIN-BD11 insulin-secreting cells. GH (500 ng/ml, 22 nm) induced a sustained increase in [Ca2+]i. The effect of GH on [Ca2+]i was prevented in the absence of extracellular Ca2+ and was inhibited by the ATP-sensitive K(+)-channel opener diazoxide and the voltage-dependent Ca(2+)-channel inhibitor nifedipine. However, GH failed to induce any changes in Ca2+ current and membrane potential, evaluated by patch-clamp recordings and by using voltage-sensitive dyes. When the intracellular Ca2+ pools had been depleted using the Ca(2+)-ATPase inhibitor thapsigargin, the effect of GH was inhibited. In addition, GH-stimulated rise in [Ca2+]i was completely abolished by ruthenium red, an inhibitor of mitochondrial Ca2+ transport, and caffeine. GH induced tyrosine phosphorylation of ryanodine receptors. The effect of GH on [Ca2+]i was completely blocked by the tyrosine kinase inhibitors genistein and lavendustin A. Interestingly, treatment of the cells with GH significantly enhanced K(+)-induced rise in [Ca2+]i. Hence, GH-stimulated rise in [Ca2+]i is dependent on extracellular Ca2+ and is mediated by Ca(2+)-induced Ca2+ release. This process is mediated by tyrosine phosphorylation of ryanodine receptors and may play a crucial role in physiological Ca2+ handling in insulin-secreting cells." @default.
• W2057074966 created "2016-06-24" @default.
• W2057074966 creator A5003338125 @default.
• W2057074966 creator A5009609459 @default.
• W2057074966 creator A5053447705 @default.
• W2057074966 creator A5060957183 @default.
• W2057074966 creator A5066383694 @default.
• W2057074966 creator A5074543896 @default.
• W2057074966 date "2004-07-01" @default.
• W2057074966 modified "2023-10-01" @default.
• W2057074966 title "Growth Hormone Promotes Ca²⁺-Induced Ca²⁺Release in Insulin-Secreting Cells by Ryanodine Receptor Tyrosine Phosphorylation" @default.
• W2057074966 cites W1533966875 @default.
• W2057074966 cites W1793072491 @default.
• W2057074966 cites W1914131776 @default.
• W2057074966 cites W1944715928 @default.
• W2057074966 cites W1974117849 @default.
• W2057074966 cites W1977040213 @default.
• W2057074966 cites W1979967204 @default.
• W2057074966 cites W1995526208 @default.
• W2057074966 cites W2000334213 @default.
• W2057074966 cites W2001479401 @default.
• W2057074966 cites W2001629507 @default.
• W2057074966 cites W2008797633 @default.
• W2057074966 cites W2014011179 @default.
• W2057074966 cites W2016242736 @default.
• W2057074966 cites W2018187509 @default.
• W2057074966 cites W2025065705 @default.
• W2057074966 cites W2032815192 @default.
• W2057074966 cites W2035920388 @default.
• W2057074966 cites W2038780532 @default.
• W2057074966 cites W2042920839 @default.
• W2057074966 cites W2047510863 @default.
• W2057074966 cites W2053736659 @default.
• W2057074966 cites W2053965162 @default.
• W2057074966 cites W2067962261 @default.
• W2057074966 cites W2068025670 @default.
• W2057074966 cites W2069210984 @default.
• W2057074966 cites W2072319961 @default.
• W2057074966 cites W2076384379 @default.
• W2057074966 cites W2085191605 @default.
• W2057074966 cites W2091368852 @default.
• W2057074966 cites W2095450310 @default.
• W2057074966 cites W2095453724 @default.
• W2057074966 cites W2102515007 @default.
• W2057074966 cites W2103869501 @default.
• W2057074966 cites W2105096335 @default.
• W2057074966 cites W2110160705 @default.
• W2057074966 cites W2114033090 @default.
• W2057074966 cites W2118979779 @default.
• W2057074966 cites W2122224574 @default.
• W2057074966 cites W2122381963 @default.
• W2057074966 cites W2128167237 @default.
• W2057074966 cites W2129137447 @default.
• W2057074966 cites W2140313980 @default.
• W2057074966 cites W2141160128 @default.
• W2057074966 cites W2141385342 @default.
• W2057074966 cites W2145011200 @default.
• W2057074966 cites W2152418833 @default.
• W2057074966 cites W2167980183 @default.
• W2057074966 cites W2171273632 @default.
• W2057074966 cites W2270672917 @default.
• W2057074966 cites W2320181845 @default.
• W2057074966 cites W2410027718 @default.
• W2057074966 cites W298238187 @default.
• W2057074966 doi "https://doi.org/10.1210/me.2004-0044" @default.
• W2057074966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15056730" @default.
• W2057074966 hasPublicationYear "2004" @default.
• W2057074966 type Work @default.
• W2057074966 sameAs 2057074966 @default.
• W2057074966 citedByCount "22" @default.
• W2057074966 countsByYear W20570749662012 @default.
• W2057074966 countsByYear W20570749662013 @default.
• W2057074966 countsByYear W20570749662015 @default.
• W2057074966 countsByYear W20570749662016 @default.
• W2057074966 countsByYear W20570749662017 @default.
• W2057074966 countsByYear W20570749662018 @default.
• W2057074966 countsByYear W20570749662019 @default.
• W2057074966 countsByYear W20570749662021 @default.
• W2057074966 crossrefType "journal-article" @default.
• W2057074966 hasAuthorship W2057074966A5003338125 @default.
• W2057074966 hasAuthorship W2057074966A5009609459 @default.
• W2057074966 hasAuthorship W2057074966A5053447705 @default.
• W2057074966 hasAuthorship W2057074966A5060957183 @default.
• W2057074966 hasAuthorship W2057074966A5066383694 @default.
• W2057074966 hasAuthorship W2057074966A5074543896 @default.
• W2057074966 hasBestOaLocation W20570749661 @default.
• W2057074966 hasConcept C113217602 @default.
• W2057074966 hasConcept C11960822 @default.
• W2057074966 hasConcept C126322002 @default.
• W2057074966 hasConcept C134018914 @default.
• W2057074966 hasConcept C170493617 @default.
• W2057074966 hasConcept C2777146706 @default.
• W2057074966 hasConcept C2777553839 @default.
• W2057074966 hasConcept C2779657890 @default.
• W2057074966 hasConcept C28406088 @default.
• W2057074966 hasConcept C42362537 @default.
• W2057074966 hasConcept C519063684 @default.
• W2057074966 hasConcept C55493867 @default.

• next