Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057081246> ?p ?o ?g. }
- W2057081246 endingPage "429" @default.
- W2057081246 startingPage "425" @default.
- W2057081246 abstract "□ The solubility of miconazole in water increased in the presence of cyclodextrins (CDs). The apparent K1:1 values calculated from the phase solubility diagrams of γ-CD, hydroxypropyl-β-CD, α-CD, hydroxyethyl-β-CD, hydroxypropyl-γ-CD, and ß-CD were 695±39.6, 363±34.1, 333±18.5, 312±31.0, 305±27.6, and 293±17.6 M-1, respectively. Solid 1:1 molar complexes were prepared by freeze-drying and kneading and characterized by UV spectroscopy, differential scanning calorimetry, and electron microscopy. The dissolution rate increased to 28-255-fold and the solubility to 9-55-fold. Oral bioavailability in rats increased to 2.3-fold by complexation with hydroxypropyl-β-CD. Human cadaver skin retained 2.6-fold more drug from the miconazole/α-CD complex and hairless mice skin retained 8.4-fold more drug from the HP-β-CD complex than from miconazole solution alone in 24 h." @default.
- W2057081246 created "2016-06-24" @default.
- W2057081246 creator A5024616701 @default.
- W2057081246 creator A5042474329 @default.
- W2057081246 creator A5075270511 @default.
- W2057081246 creator A5078965362 @default.
- W2057081246 date "1998-04-01" @default.
- W2057081246 modified "2023-10-17" @default.
- W2057081246 title "Preparation Characterization Evaluation of Miconazole-Cyclodextrin Complexes for Improved Oral Topical Delivery" @default.
- W2057081246 cites W1966460316 @default.
- W2057081246 cites W1971219620 @default.
- W2057081246 cites W1987392192 @default.
- W2057081246 cites W1996039844 @default.
- W2057081246 cites W2024311283 @default.
- W2057081246 cites W2024381570 @default.
- W2057081246 cites W2027650731 @default.
- W2057081246 cites W2054384419 @default.
- W2057081246 cites W2065651904 @default.
- W2057081246 cites W2094205187 @default.
- W2057081246 cites W2131259223 @default.
- W2057081246 cites W2152049632 @default.
- W2057081246 cites W65348551 @default.
- W2057081246 doi "https://doi.org/10.1021/js970361l" @default.
- W2057081246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9548893" @default.
- W2057081246 hasPublicationYear "1998" @default.
- W2057081246 type Work @default.
- W2057081246 sameAs 2057081246 @default.
- W2057081246 citedByCount "102" @default.
- W2057081246 countsByYear W20570812462012 @default.
- W2057081246 countsByYear W20570812462013 @default.
- W2057081246 countsByYear W20570812462014 @default.
- W2057081246 countsByYear W20570812462015 @default.
- W2057081246 countsByYear W20570812462016 @default.
- W2057081246 countsByYear W20570812462017 @default.
- W2057081246 countsByYear W20570812462018 @default.
- W2057081246 countsByYear W20570812462019 @default.
- W2057081246 countsByYear W20570812462020 @default.
- W2057081246 countsByYear W20570812462021 @default.
- W2057081246 countsByYear W20570812462022 @default.
- W2057081246 countsByYear W20570812462023 @default.
- W2057081246 crossrefType "journal-article" @default.
- W2057081246 hasAuthorship W2057081246A5024616701 @default.
- W2057081246 hasAuthorship W2057081246A5042474329 @default.
- W2057081246 hasAuthorship W2057081246A5075270511 @default.
- W2057081246 hasAuthorship W2057081246A5078965362 @default.
- W2057081246 hasConcept C121332964 @default.
- W2057081246 hasConcept C13965031 @default.
- W2057081246 hasConcept C155574463 @default.
- W2057081246 hasConcept C16005928 @default.
- W2057081246 hasConcept C178790620 @default.
- W2057081246 hasConcept C181389837 @default.
- W2057081246 hasConcept C185592680 @default.
- W2057081246 hasConcept C2777229883 @default.
- W2057081246 hasConcept C2779156968 @default.
- W2057081246 hasConcept C2779433975 @default.
- W2057081246 hasConcept C2779548794 @default.
- W2057081246 hasConcept C39519442 @default.
- W2057081246 hasConcept C43617362 @default.
- W2057081246 hasConcept C55493867 @default.
- W2057081246 hasConcept C71924100 @default.
- W2057081246 hasConcept C88380143 @default.
- W2057081246 hasConcept C97355855 @default.
- W2057081246 hasConcept C98274493 @default.
- W2057081246 hasConceptScore W2057081246C121332964 @default.
- W2057081246 hasConceptScore W2057081246C13965031 @default.
- W2057081246 hasConceptScore W2057081246C155574463 @default.
- W2057081246 hasConceptScore W2057081246C16005928 @default.
- W2057081246 hasConceptScore W2057081246C178790620 @default.
- W2057081246 hasConceptScore W2057081246C181389837 @default.
- W2057081246 hasConceptScore W2057081246C185592680 @default.
- W2057081246 hasConceptScore W2057081246C2777229883 @default.
- W2057081246 hasConceptScore W2057081246C2779156968 @default.
- W2057081246 hasConceptScore W2057081246C2779433975 @default.
- W2057081246 hasConceptScore W2057081246C2779548794 @default.
- W2057081246 hasConceptScore W2057081246C39519442 @default.
- W2057081246 hasConceptScore W2057081246C43617362 @default.
- W2057081246 hasConceptScore W2057081246C55493867 @default.
- W2057081246 hasConceptScore W2057081246C71924100 @default.
- W2057081246 hasConceptScore W2057081246C88380143 @default.
- W2057081246 hasConceptScore W2057081246C97355855 @default.
- W2057081246 hasConceptScore W2057081246C98274493 @default.
- W2057081246 hasIssue "4" @default.
- W2057081246 hasLocation W20570812461 @default.
- W2057081246 hasLocation W20570812462 @default.
- W2057081246 hasOpenAccess W2057081246 @default.
- W2057081246 hasPrimaryLocation W20570812461 @default.
- W2057081246 hasRelatedWork W1565824455 @default.
- W2057081246 hasRelatedWork W2007472458 @default.
- W2057081246 hasRelatedWork W2012672635 @default.
- W2057081246 hasRelatedWork W2077782996 @default.
- W2057081246 hasRelatedWork W2101670109 @default.
- W2057081246 hasRelatedWork W2375232753 @default.
- W2057081246 hasRelatedWork W2383263348 @default.
- W2057081246 hasRelatedWork W2388312637 @default.
- W2057081246 hasRelatedWork W2943671407 @default.
- W2057081246 hasRelatedWork W2974328145 @default.
- W2057081246 hasVolume "87" @default.
- W2057081246 isParatext "false" @default.