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• W2057091264 abstract "<h2>ABSTRACT</h2> <i>In vitro</i> dissolution tests are performed for new formulations to evaluate <i>in vivo</i> performance, which is affected by the change of gastrointestinal (GI) physiology, in the GI tract. Thus, those environmental changes should be introduced to an <i>in vitro</i> dissolution test. Many studies have successfully shown the improvement of <i>in vitro</i>–<i>in vivo</i> correlations (IVIVC) by introducing those physiological changes into dissolution tests. The gastrointestinal simulator (GIS), a multicompartment <i>in vitro</i> dissolution apparatus, was developed to evaluate <i>in vivo</i> drug dissolution. A gastric-emptying rate along with transit rate are key factors to evaluate <i>in vivo</i> drug dissolution and, hence, drug absorption. Dissolution tests with the GIS were performed with Biopharmaceutical Classification System class I drugs at five different gastric-emptying rates in the fasted state. Computational models were used to determine <i>in vivo</i> gastric-emptying time for propranolol and metoprolol based on the GIS dissolution results. Those were compared with published clinical data to determine the gastric half-emptying time. In conclusion, the GIS is a practical tool to assess dissolution properties and can improve IVIVC. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3416–3422, 2014" @default.
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• W2057091264 date "2014-11-01" @default.
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• W2057091264 title "Evaluation of a Three Compartment In Vitro Gastrointestinal Simulator Dissolution Apparatus to Predict In Vivo Dissolution" @default.
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• W2057091264 doi "https://doi.org/10.1002/jps.24112" @default.
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