FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057100229> ?p ?o ?g. }

• W2057100229 endingPage "38" @default.
• W2057100229 startingPage "27" @default.
• W2057100229 abstract "The increasing industrial use of nanomaterials during the last decades poses a potential threat to the environment and in particular to organisms living in the aquatic environment. In the present study, the toxicity of zinc oxide nanoparticles (ZnONP) was investigated in Pacific oysters Crassostrea gigas. The nanoscale of ZnONP, in vehicle or ultrapure water, was confirmed, presenting an average size ranging from 28 to 88 nm. In seawater, aggregation was detected by TEM and DLS analysis, with an increased average size ranging from 1 to 2 μm. Soluble or nanoparticulated zinc presented similar toxicity, displaying a LC50 (96 h) around 30 mg/L. High zinc dissociation from ZnONP, releasing ionic zinc in seawater, is a potential route for zinc assimilation and ZnONP toxicity. To investigate mechanisms of toxicity, oysters were treated with 4 mg/L ZnONP for 6, 24 or 48 h. ZnONP accumulated in gills (24 and 48 h) and digestive glands (48 h). Ultrastructural analysis of gills revealed electron-dense vesicles near the cell membrane and loss of mitochondrial cristae (6 h). Swollen mitochondria and a more conspicuous loss of mitochondrial cristae were observed after 24 h. Mitochondria with disrupted membranes and an increased number of cytosolic vesicles displaying electron-dense material were observed 48 h post exposure. Digestive gland showed similar changes, but these were delayed relative to gills. ZnONP exposure did not greatly affect thiol homeostasis (reduced and oxidized glutathione) or immunological parameters (phagocytosis, hemocyte viability and activation and total hemocyte count). At 24 h post exposure, decreased (−29%) glutathione reductase (GR) activity was observed in gills, but other biochemical responses were observed only after 48 h of exposure: lower GR activity (−28%) and levels of protein thiols (−21%), increased index of lipid peroxidation (+49%) and GPx activity (+26%). In accordance with ultrastructural changes and zinc load, digestive gland showed delayed biochemical responses. Except for a decreased GR activity (−47%) at 48 h post exposure, the biochemical alterations seen in gills were not present in digestive gland. The results indicate that gills are able to incorporate zinc prior (24 h) to digestive gland (48 h), leading to earlier mitochondrial disruption and oxidative stress. Our data suggest that gills are the initial target of ZnONP and that mitochondria are organelles particularly susceptible to ZnONP in C. gigas." @default.
• W2057100229 created "2016-06-24" @default.
• W2057100229 creator A5021132760 @default.
• W2057100229 creator A5023156959 @default.
• W2057100229 creator A5028422116 @default.
• W2057100229 creator A5030776667 @default.
• W2057100229 creator A5032412369 @default.
• W2057100229 creator A5033712903 @default.
• W2057100229 creator A5038152793 @default.
• W2057100229 creator A5041102359 @default.
• W2057100229 creator A5047436623 @default.
• W2057100229 creator A5049265897 @default.
• W2057100229 creator A5076524663 @default.
• W2057100229 creator A5080178391 @default.
• W2057100229 date "2014-08-01" @default.
• W2057100229 modified "2023-10-16" @default.
• W2057100229 title "Gills are an initial target of zinc oxide nanoparticles in oysters Crassostrea gigas, leading to mitochondrial disruption and oxidative stress" @default.
• W2057100229 cites W1122013619 @default.
• W2057100229 cites W1498636565 @default.
• W2057100229 cites W1504571050 @default.
• W2057100229 cites W1585958439 @default.
• W2057100229 cites W191793640 @default.
• W2057100229 cites W1966626824 @default.
• W2057100229 cites W1968953482 @default.
• W2057100229 cites W1969234662 @default.
• W2057100229 cites W1969502837 @default.
• W2057100229 cites W1973506120 @default.
• W2057100229 cites W1975367193 @default.
• W2057100229 cites W1976771548 @default.
• W2057100229 cites W1979626661 @default.
• W2057100229 cites W1984087905 @default.
• W2057100229 cites W1986034347 @default.
• W2057100229 cites W1990236958 @default.
• W2057100229 cites W1993846090 @default.
• W2057100229 cites W1997823158 @default.
• W2057100229 cites W1999602209 @default.
• W2057100229 cites W2004815940 @default.
• W2057100229 cites W2006157006 @default.
• W2057100229 cites W2008097708 @default.
• W2057100229 cites W2009570575 @default.
• W2057100229 cites W2011424097 @default.
• W2057100229 cites W2012489625 @default.
• W2057100229 cites W2012837919 @default.
• W2057100229 cites W2016423419 @default.
• W2057100229 cites W2017019174 @default.
• W2057100229 cites W2029221276 @default.
• W2057100229 cites W2029394583 @default.
• W2057100229 cites W2036839645 @default.
• W2057100229 cites W2036948210 @default.
• W2057100229 cites W2037360063 @default.
• W2057100229 cites W2040301157 @default.
• W2057100229 cites W2042579891 @default.
• W2057100229 cites W2044061165 @default.
• W2057100229 cites W2048037169 @default.
• W2057100229 cites W2048672005 @default.
• W2057100229 cites W2051055054 @default.
• W2057100229 cites W2055105871 @default.
• W2057100229 cites W2063666940 @default.
• W2057100229 cites W2072755860 @default.
• W2057100229 cites W2074013606 @default.
• W2057100229 cites W2076133681 @default.
• W2057100229 cites W2076191328 @default.
• W2057100229 cites W2076617147 @default.
• W2057100229 cites W2077972966 @default.
• W2057100229 cites W2081672199 @default.
• W2057100229 cites W2082102612 @default.
• W2057100229 cites W2082734141 @default.
• W2057100229 cites W2085298128 @default.
• W2057100229 cites W2091610465 @default.
• W2057100229 cites W2092615232 @default.
• W2057100229 cites W2104824608 @default.
• W2057100229 cites W2111342851 @default.
• W2057100229 cites W2117326659 @default.
• W2057100229 cites W2121395439 @default.
• W2057100229 cites W2126519286 @default.
• W2057100229 cites W2126793111 @default.
• W2057100229 cites W2141560029 @default.
• W2057100229 cites W2142827018 @default.
• W2057100229 cites W2145857667 @default.
• W2057100229 cites W2147929482 @default.
• W2057100229 cites W2151197152 @default.
• W2057100229 cites W2154952923 @default.
• W2057100229 cites W2167934012 @default.
• W2057100229 cites W2197332903 @default.
• W2057100229 cites W3021181849 @default.
• W2057100229 cites W4293247451 @default.
• W2057100229 cites W73347127 @default.
• W2057100229 doi "https://doi.org/10.1016/j.aquatox.2014.03.018" @default.
• W2057100229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24745718" @default.
• W2057100229 hasPublicationYear "2014" @default.
• W2057100229 type Work @default.
• W2057100229 sameAs 2057100229 @default.
• W2057100229 citedByCount "75" @default.
• W2057100229 countsByYear W20571002292014 @default.
• W2057100229 countsByYear W20571002292015 @default.
• W2057100229 countsByYear W20571002292016 @default.
• W2057100229 countsByYear W20571002292017 @default.
• W2057100229 countsByYear W20571002292018 @default.

• next