FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057100530> ?p ?o ?g. }

• W2057100530 endingPage "964" @default.
• W2057100530 startingPage "956" @default.
• W2057100530 abstract "To investigate the entire human corneal nerve architecture of donors with different durations of insulin-dependent diabetes mellitus (IDDM).Experimental study.Sixteen fresh human eyes from 8 diabetic donors (aged 43-66 years, with IDDM for 2-17 years) and 12 eyes from 6 normal donors (aged from 44-67 years) were obtained from the National Disease Research Interchange (NDRI).After fixation, corneas were stained with mouse monoclonal anti-β-Tubulin III antibody, and images were acquired to build a whole view of the corneal nerve architecture. The same corneas were used for both whole-mount and cross-section examination.Corneal epithelial nerve density was calculated on the basis of the whole-mount view of the central area. The number of stromal nerves was calculated by counting the nerve trunks at the corneoscleral limbus of the entire cornea. Differences between diabetic and normal corneas in epithelial nerve densities and main stromal nerve numbers were compared by paired-samples t test.The diabetic eyes presented numerous neuropathies in areas where the epithelial nerve bundles emerged. A striking pathologic change was the presence of abundant nerve fiber loops in the stroma. These loops seemed to form by resistance presented by the basement membrane, which may prevent penetration of stromal nerve branches into epithelia. There was no difference in the numbers of main stromal nerve trunks between corneas from diabetic and normal donors, but there was a significant decrease in central epithelial nerve density in the diabetic corneas. We did not find an age effect on this decrease. Instead, it was significantly affected by 5 or more years of IDDM.This is the first study to show an entire view of the nerve architecture in human diabetic corneas. The decreased epithelial nerve density may result from the abnormalities of stromal nerve architecture and is affected by 5 or more years of IDDM. Although compensation for some nerve regeneration takes place, the alterations in the stromal nerves can explain the poor healing and persistent epithelial defects seen in diabetic patients." @default.
• W2057100530 created "2016-06-24" @default.
• W2057100530 creator A5015926296 @default.
• W2057100530 creator A5062196910 @default.
• W2057100530 date "2012-05-01" @default.
• W2057100530 modified "2023-09-30" @default.
• W2057100530 title "Mapping the Nerve Architecture of Diabetic Human Corneas" @default.
• W2057100530 cites W1601094292 @default.
• W2057100530 cites W1739691545 @default.
• W2057100530 cites W1976551303 @default.
• W2057100530 cites W1978310045 @default.
• W2057100530 cites W1982402889 @default.
• W2057100530 cites W1982800408 @default.
• W2057100530 cites W1983711728 @default.
• W2057100530 cites W1993891259 @default.
• W2057100530 cites W1994049385 @default.
• W2057100530 cites W1996413213 @default.
• W2057100530 cites W2014580941 @default.
• W2057100530 cites W2021650764 @default.
• W2057100530 cites W2031219030 @default.
• W2057100530 cites W2036296920 @default.
• W2057100530 cites W2041225472 @default.
• W2057100530 cites W2045575059 @default.
• W2057100530 cites W2045964960 @default.
• W2057100530 cites W2048638072 @default.
• W2057100530 cites W2048720040 @default.
• W2057100530 cites W2054411776 @default.
• W2057100530 cites W2057181066 @default.
• W2057100530 cites W2060175573 @default.
• W2057100530 cites W2066730413 @default.
• W2057100530 cites W2089049880 @default.
• W2057100530 cites W2102450673 @default.
• W2057100530 cites W2107361477 @default.
• W2057100530 cites W2113689119 @default.
• W2057100530 cites W2117326627 @default.
• W2057100530 cites W2118513878 @default.
• W2057100530 cites W2125192579 @default.
• W2057100530 cites W2139701121 @default.
• W2057100530 cites W2337729957 @default.
• W2057100530 cites W48937670 @default.
• W2057100530 doi "https://doi.org/10.1016/j.ophtha.2011.10.036" @default.
• W2057100530 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3480080" @default.
• W2057100530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22325488" @default.
• W2057100530 hasPublicationYear "2012" @default.
• W2057100530 type Work @default.
• W2057100530 sameAs 2057100530 @default.
• W2057100530 citedByCount "62" @default.
• W2057100530 countsByYear W20571005302012 @default.
• W2057100530 countsByYear W20571005302013 @default.
• W2057100530 countsByYear W20571005302014 @default.
• W2057100530 countsByYear W20571005302015 @default.
• W2057100530 countsByYear W20571005302016 @default.
• W2057100530 countsByYear W20571005302017 @default.
• W2057100530 countsByYear W20571005302018 @default.
• W2057100530 countsByYear W20571005302019 @default.
• W2057100530 countsByYear W20571005302020 @default.
• W2057100530 countsByYear W20571005302021 @default.
• W2057100530 countsByYear W20571005302022 @default.
• W2057100530 countsByYear W20571005302023 @default.
• W2057100530 crossrefType "journal-article" @default.
• W2057100530 hasAuthorship W2057100530A5015926296 @default.
• W2057100530 hasAuthorship W2057100530A5062196910 @default.
• W2057100530 hasBestOaLocation W20571005302 @default.
• W2057100530 hasConcept C105702510 @default.
• W2057100530 hasConcept C118487528 @default.
• W2057100530 hasConcept C134018914 @default.
• W2057100530 hasConcept C142724271 @default.
• W2057100530 hasConcept C16930146 @default.
• W2057100530 hasConcept C204232928 @default.
• W2057100530 hasConcept C2776193487 @default.
• W2057100530 hasConcept C2776823239 @default.
• W2057100530 hasConcept C2776882836 @default.
• W2057100530 hasConcept C2777723521 @default.
• W2057100530 hasConcept C52124034 @default.
• W2057100530 hasConcept C555293320 @default.
• W2057100530 hasConcept C71924100 @default.
• W2057100530 hasConceptScore W2057100530C105702510 @default.
• W2057100530 hasConceptScore W2057100530C118487528 @default.
• W2057100530 hasConceptScore W2057100530C134018914 @default.
• W2057100530 hasConceptScore W2057100530C142724271 @default.
• W2057100530 hasConceptScore W2057100530C16930146 @default.
• W2057100530 hasConceptScore W2057100530C204232928 @default.
• W2057100530 hasConceptScore W2057100530C2776193487 @default.
• W2057100530 hasConceptScore W2057100530C2776823239 @default.
• W2057100530 hasConceptScore W2057100530C2776882836 @default.
• W2057100530 hasConceptScore W2057100530C2777723521 @default.
• W2057100530 hasConceptScore W2057100530C52124034 @default.
• W2057100530 hasConceptScore W2057100530C555293320 @default.
• W2057100530 hasConceptScore W2057100530C71924100 @default.
• W2057100530 hasFunder F4320306811 @default.
• W2057100530 hasFunder F4320337350 @default.
• W2057100530 hasIssue "5" @default.
• W2057100530 hasLocation W20571005301 @default.
• W2057100530 hasLocation W20571005302 @default.
• W2057100530 hasLocation W20571005303 @default.
• W2057100530 hasLocation W20571005304 @default.
• W2057100530 hasOpenAccess W2057100530 @default.
• W2057100530 hasPrimaryLocation W20571005301 @default.

• next