FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057100819> ?p ?o ?g. }

• W2057100819 endingPage "257" @default.
• W2057100819 startingPage "252" @default.
• W2057100819 abstract "The surface protein Spr1345 from Streptococcus pneumoniae R6 is a 22-kDa mucin-binding protein (MucBP) involved in adherence and colonization of the human lung and respiratory tract. It is composed of a mucin-binding domain (MucBD) and a proline-rich domain (PRD) followed by an LPxTG motif, which is recognized and cleaved by sortase, resulting in a mature form of 171 residues (MF171) that is anchored to the cell wall. We found that the MucBD alone possesses comparable in vitro mucin-binding affinity to the mature form, and can be specifically enriched at the surface of human lung carcinoma A549 cells. Using single-wavelength anomalous dispersion (SAD) phasing method with the iodine signals, we solved the crystal structure of the MucBD at 2.0 Å resolution, the first structure of MucBDs from pathogenic bacteria. The overall structure adopts an immunoglobulin-like fold with an elongated rod-like shape, composed of six anti-parallel β-strands and a long loop. Structural comparison suggested that the conserved C-terminal moiety may participate in the recognition of mucins. These findings provided structural insights into host-pathogen interaction mediated by mucins, which might be useful for designing novel vaccines and antibiotic drugs against human diseases caused by pneumococci." @default.
• W2057100819 created "2016-06-24" @default.
• W2057100819 creator A5018857219 @default.
• W2057100819 creator A5019668551 @default.
• W2057100819 creator A5024550420 @default.
• W2057100819 creator A5031994389 @default.
• W2057100819 creator A5038404795 @default.
• W2057100819 creator A5039768705 @default.
• W2057100819 creator A5040706517 @default.
• W2057100819 creator A5055611337 @default.
• W2057100819 creator A5075702310 @default.
• W2057100819 creator A5087074383 @default.
• W2057100819 date "2011-04-01" @default.
• W2057100819 modified "2023-10-07" @default.
• W2057100819 title "Crystal structure of the mucin-binding domain of Spr1345 from Streptococcus pneumoniae" @default.
• W2057100819 cites W1843397982 @default.
• W2057100819 cites W1913862483 @default.
• W2057100819 cites W1979880724 @default.
• W2057100819 cites W1986191025 @default.
• W2057100819 cites W1991863242 @default.
• W2057100819 cites W2011374678 @default.
• W2057100819 cites W2021148491 @default.
• W2057100819 cites W2029535061 @default.
• W2057100819 cites W2034767282 @default.
• W2057100819 cites W2038840577 @default.
• W2057100819 cites W2066080177 @default.
• W2057100819 cites W2066694476 @default.
• W2057100819 cites W2075549740 @default.
• W2057100819 cites W2119483434 @default.
• W2057100819 cites W2122339645 @default.
• W2057100819 cites W2122379209 @default.
• W2057100819 cites W2131350133 @default.
• W2057100819 cites W2131885678 @default.
• W2057100819 cites W2138659044 @default.
• W2057100819 cites W2144081223 @default.
• W2057100819 cites W2145435157 @default.
• W2057100819 cites W2165354823 @default.
• W2057100819 cites W2166211977 @default.
• W2057100819 cites W2168613507 @default.
• W2057100819 cites W2169510298 @default.
• W2057100819 doi "https://doi.org/10.1016/j.jsb.2010.10.016" @default.
• W2057100819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21055474" @default.
• W2057100819 hasPublicationYear "2011" @default.
• W2057100819 type Work @default.
• W2057100819 sameAs 2057100819 @default.
• W2057100819 citedByCount "22" @default.
• W2057100819 countsByYear W20571008192012 @default.
• W2057100819 countsByYear W20571008192013 @default.
• W2057100819 countsByYear W20571008192014 @default.
• W2057100819 countsByYear W20571008192015 @default.
• W2057100819 countsByYear W20571008192016 @default.
• W2057100819 countsByYear W20571008192017 @default.
• W2057100819 countsByYear W20571008192019 @default.
• W2057100819 countsByYear W20571008192020 @default.
• W2057100819 countsByYear W20571008192022 @default.
• W2057100819 countsByYear W20571008192023 @default.
• W2057100819 crossrefType "journal-article" @default.
• W2057100819 hasAuthorship W2057100819A5018857219 @default.
• W2057100819 hasAuthorship W2057100819A5019668551 @default.
• W2057100819 hasAuthorship W2057100819A5024550420 @default.
• W2057100819 hasAuthorship W2057100819A5031994389 @default.
• W2057100819 hasAuthorship W2057100819A5038404795 @default.
• W2057100819 hasAuthorship W2057100819A5039768705 @default.
• W2057100819 hasAuthorship W2057100819A5040706517 @default.
• W2057100819 hasAuthorship W2057100819A5055611337 @default.
• W2057100819 hasAuthorship W2057100819A5075702310 @default.
• W2057100819 hasAuthorship W2057100819A5087074383 @default.
• W2057100819 hasConcept C179264091 @default.
• W2057100819 hasConcept C185592680 @default.
• W2057100819 hasConcept C19655278 @default.
• W2057100819 hasConcept C2781253189 @default.
• W2057100819 hasConcept C501593827 @default.
• W2057100819 hasConcept C523546767 @default.
• W2057100819 hasConcept C54355233 @default.
• W2057100819 hasConcept C55493867 @default.
• W2057100819 hasConcept C86803240 @default.
• W2057100819 hasConcept C89423630 @default.
• W2057100819 hasConceptScore W2057100819C179264091 @default.
• W2057100819 hasConceptScore W2057100819C185592680 @default.
• W2057100819 hasConceptScore W2057100819C19655278 @default.
• W2057100819 hasConceptScore W2057100819C2781253189 @default.
• W2057100819 hasConceptScore W2057100819C501593827 @default.
• W2057100819 hasConceptScore W2057100819C523546767 @default.
• W2057100819 hasConceptScore W2057100819C54355233 @default.
• W2057100819 hasConceptScore W2057100819C55493867 @default.
• W2057100819 hasConceptScore W2057100819C86803240 @default.
• W2057100819 hasConceptScore W2057100819C89423630 @default.
• W2057100819 hasFunder F4320321001 @default.
• W2057100819 hasIssue "1" @default.
• W2057100819 hasLocation W20571008191 @default.
• W2057100819 hasLocation W20571008192 @default.
• W2057100819 hasOpenAccess W2057100819 @default.
• W2057100819 hasPrimaryLocation W20571008191 @default.
• W2057100819 hasRelatedWork W1497388576 @default.
• W2057100819 hasRelatedWork W1641042124 @default.
• W2057100819 hasRelatedWork W1990804418 @default.
• W2057100819 hasRelatedWork W1993764875 @default.
• W2057100819 hasRelatedWork W2013243191 @default.

• next