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- W2057102446 abstract "Upon the invasion of pathogens, the immune system needs to mount defense responses immediately. Over the past 10 years, Toll-like receptors (TLRs) have been discovered in mammals and defined as pathogen sensors. TLRs are considered to bind directly to ligands, discriminate them immediately, and induce defense responses when appropriate. We here review microbial recognition by TLRs, downstream signaling, and the relationship of TLRs to susceptibility to infectious diseases and immune disorders. Recent reports have revealed a requirement for co-receptors in TLR responses. A TLR signaling pathway is required for protection against infectious diseases, but excessive signaling may lead to allergies, autoimmune diseases, or atherosclerosis. In humans, several deficiencies of signaling molecules downstream of TLRs, and TLR polymorphisms that affect recognition or signaling, were reported to cause immunodeficiencies. It is important to understand how TLR signaling is controlled." @default.
- W2057102446 created "2016-06-24" @default.
- W2057102446 creator A5037176798 @default.
- W2057102446 creator A5045382494 @default.
- W2057102446 date "2006-01-01" @default.
- W2057102446 modified "2023-10-03" @default.
- W2057102446 title "Toll-like receptors (TLRs) and immune disorders" @default.
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- W2057102446 cites W1519843522 @default.
- W2057102446 cites W1519886765 @default.
- W2057102446 cites W1520365933 @default.
- W2057102446 cites W1525912444 @default.
- W2057102446 cites W1557965441 @default.
- W2057102446 cites W1584629476 @default.
- W2057102446 cites W1591714343 @default.
- W2057102446 cites W1863371111 @default.
- W2057102446 cites W1872584468 @default.
- W2057102446 cites W1898298381 @default.
- W2057102446 cites W1964985092 @default.
- W2057102446 cites W1966772446 @default.
- W2057102446 cites W1966892322 @default.
- W2057102446 cites W1969430178 @default.
- W2057102446 cites W1971799655 @default.
- W2057102446 cites W1976300852 @default.
- W2057102446 cites W1977921022 @default.
- W2057102446 cites W1980273234 @default.
- W2057102446 cites W1981045929 @default.
- W2057102446 cites W1981480267 @default.
- W2057102446 cites W1984395465 @default.
- W2057102446 cites W1986013893 @default.
- W2057102446 cites W1987410025 @default.
- W2057102446 cites W1989656760 @default.
- W2057102446 cites W1990142540 @default.
- W2057102446 cites W1991731944 @default.
- W2057102446 cites W1992517860 @default.
- W2057102446 cites W1999587028 @default.
- W2057102446 cites W2004537329 @default.
- W2057102446 cites W2011678998 @default.
- W2057102446 cites W2018788678 @default.
- W2057102446 cites W2019676172 @default.
- W2057102446 cites W2022651196 @default.
- W2057102446 cites W2025412364 @default.
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- W2057102446 cites W2038073973 @default.
- W2057102446 cites W2041521914 @default.
- W2057102446 cites W2049115723 @default.
- W2057102446 cites W2057884259 @default.
- W2057102446 cites W2066586142 @default.
- W2057102446 cites W2067678108 @default.
- W2057102446 cites W2069663822 @default.
- W2057102446 cites W2073565085 @default.
- W2057102446 cites W2083709056 @default.
- W2057102446 cites W2087867048 @default.
- W2057102446 cites W2096671043 @default.
- W2057102446 cites W2096743939 @default.
- W2057102446 cites W2107182434 @default.
- W2057102446 cites W2107674270 @default.
- W2057102446 cites W2109152623 @default.
- W2057102446 cites W2111200149 @default.
- W2057102446 cites W2119256241 @default.
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- W2057102446 cites W2126829776 @default.
- W2057102446 cites W2128364938 @default.
- W2057102446 cites W2130840482 @default.
- W2057102446 cites W2134204376 @default.
- W2057102446 cites W2134847649 @default.
- W2057102446 cites W2137590150 @default.
- W2057102446 cites W2145243874 @default.
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- W2057102446 cites W2161577497 @default.
- W2057102446 cites W2163353465 @default.
- W2057102446 cites W2164887085 @default.
- W2057102446 cites W2165591553 @default.
- W2057102446 cites W2167276755 @default.
- W2057102446 cites W2167745729 @default.
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- W2057102446 doi "https://doi.org/10.1007/s10156-006-0477-4" @default.
- W2057102446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17109085" @default.
- W2057102446 hasPublicationYear "2006" @default.
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