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- W2057110760 abstract "Introduction: ER-beta (ER-β) regulates genes involved in cellular proliferation and apoptosis, and is considered to be anti-proliferative and tumor suppressive. ER-β is frequently reduced or lost in breast cancers (BrC). ER-β can also transdominantly inhibit ER-α transcription at some genes, even in the absence of ligand. Thus, ER-β selective agonists such as diarylpropionitrile (DPN) may inhibit breast cancer cells, and may also prevent tumor initiation or tumor growth of BrC through lowering proliferation and higher apoptosis. Methods: A total of 49 Sprague-Dawley rats (19 ovariectomized (OVX) and 30 non-OVX) were treated with DMBA breast cancer carcinogen. Then the rats were separated into two groups. In the first group, the rats received daily DPN injections (1000ug/kg BW) starting immediately after DMBA administration, to observe tumor prevention or initiation. In the second, only the rats developed tumor(s) ≥ 1cm received daily DPN, to observe reduction or increase of tumor sizes. The rats were sacrificed to collect tumors and normal breast tissues, which were tested for HE 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2146. doi:10.1158/1538-7445.AM2014-2146" @default.
- W2057110760 created "2016-06-24" @default.
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- W2057110760 date "2014-09-30" @default.
- W2057110760 modified "2023-09-25" @default.
- W2057110760 title "Abstract 2146: The chemo-preventive effect of ER-β agonist on DMBA induced breast cancers" @default.
- W2057110760 doi "https://doi.org/10.1158/1538-7445.am2014-2146" @default.
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