FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057115306> ?p ?o ?g. }

• W2057115306 endingPage "5308" @default.
• W2057115306 startingPage "5292" @default.
• W2057115306 abstract "Glutamate dehydrogenase has been recently identified as a tissue‐specific histone H3‐specific clipping enzyme. We have previously shown that it cleaves free as well as chromatin‐bound histone H3. However, the physiological significance of this enzyme is still not clear. The present study aimed to improve our understanding of its significance in vivo . Using biochemical and cell biological approaches, we show that glutamate dehydrogenase is primarily associated with euchromatin, and it re‐localizes from the nuclear periphery to the nucleolus upon DNA damage. The cysteine protease inhibitor stefin B regulates the H3 clipping activity of the enzyme. Chromatin structure and certain histone modifications influence H3 clipping activity. Interestingly, we also observed that an in vivo truncated form of H3 lacks H3K56 acetylation, which is a code for the DNA damage response. Together, these results suggest that glutamate dehydrogenase is a euchromatin‐associated enzyme, and its H3 clipping activity is regulated by chromatin structure, histone modifications and an in vivo inhibitor. In response to DNA damage, it re‐localizes to the nuclei, and hence may be involved in regulation of gene expression in vivo ." @default.
• W2057115306 created "2016-06-24" @default.
• W2057115306 creator A5017878103 @default.
• W2057115306 creator A5020632202 @default.
• W2057115306 creator A5044702453 @default.
• W2057115306 date "2014-10-27" @default.
• W2057115306 modified "2023-10-03" @default.
• W2057115306 title "H3 clipping activity of glutamate dehydrogenase is regulated by stefin B and chromatin structure" @default.
• W2057115306 cites W1965975821 @default.
• W2057115306 cites W1985775217 @default.
• W2057115306 cites W1988754209 @default.
• W2057115306 cites W1990103859 @default.
• W2057115306 cites W1991978196 @default.
• W2057115306 cites W2002698073 @default.
• W2057115306 cites W2014258552 @default.
• W2057115306 cites W2020414894 @default.
• W2057115306 cites W2025305964 @default.
• W2057115306 cites W2031392820 @default.
• W2057115306 cites W2032059333 @default.
• W2057115306 cites W2035915355 @default.
• W2057115306 cites W2041773888 @default.
• W2057115306 cites W2048645295 @default.
• W2057115306 cites W2052169804 @default.
• W2057115306 cites W2053767654 @default.
• W2057115306 cites W2054169699 @default.
• W2057115306 cites W2055279201 @default.
• W2057115306 cites W2075213209 @default.
• W2057115306 cites W2079351750 @default.
• W2057115306 cites W2088572359 @default.
• W2057115306 cites W2094813903 @default.
• W2057115306 cites W2095884976 @default.
• W2057115306 cites W2096707410 @default.
• W2057115306 cites W2103427783 @default.
• W2057115306 cites W2108709147 @default.
• W2057115306 cites W2116989970 @default.
• W2057115306 cites W2144792857 @default.
• W2057115306 cites W2145929363 @default.
• W2057115306 cites W2160718564 @default.
• W2057115306 cites W2161500231 @default.
• W2057115306 cites W2164678569 @default.
• W2057115306 cites W4236213294 @default.
• W2057115306 doi "https://doi.org/10.1111/febs.13069" @default.
• W2057115306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25263734" @default.
• W2057115306 hasPublicationYear "2014" @default.
• W2057115306 type Work @default.
• W2057115306 sameAs 2057115306 @default.
• W2057115306 citedByCount "13" @default.
• W2057115306 countsByYear W20571153062015 @default.
• W2057115306 countsByYear W20571153062016 @default.
• W2057115306 countsByYear W20571153062017 @default.
• W2057115306 countsByYear W20571153062018 @default.
• W2057115306 countsByYear W20571153062019 @default.
• W2057115306 countsByYear W20571153062020 @default.
• W2057115306 crossrefType "journal-article" @default.
• W2057115306 hasAuthorship W2057115306A5017878103 @default.
• W2057115306 hasAuthorship W2057115306A5020632202 @default.
• W2057115306 hasAuthorship W2057115306A5044702453 @default.
• W2057115306 hasBestOaLocation W20571153061 @default.
• W2057115306 hasConcept C10058791 @default.
• W2057115306 hasConcept C100924687 @default.
• W2057115306 hasConcept C101152365 @default.
• W2057115306 hasConcept C103435993 @default.
• W2057115306 hasConcept C104317684 @default.
• W2057115306 hasConcept C150194340 @default.
• W2057115306 hasConcept C150425827 @default.
• W2057115306 hasConcept C153911025 @default.
• W2057115306 hasConcept C190727270 @default.
• W2057115306 hasConcept C22709980 @default.
• W2057115306 hasConcept C2776745794 @default.
• W2057115306 hasConcept C552990157 @default.
• W2057115306 hasConcept C55493867 @default.
• W2057115306 hasConcept C56428682 @default.
• W2057115306 hasConcept C64927066 @default.
• W2057115306 hasConcept C83640560 @default.
• W2057115306 hasConcept C84772758 @default.
• W2057115306 hasConcept C86803240 @default.
• W2057115306 hasConcept C95444343 @default.
• W2057115306 hasConceptScore W2057115306C10058791 @default.
• W2057115306 hasConceptScore W2057115306C100924687 @default.
• W2057115306 hasConceptScore W2057115306C101152365 @default.
• W2057115306 hasConceptScore W2057115306C103435993 @default.
• W2057115306 hasConceptScore W2057115306C104317684 @default.
• W2057115306 hasConceptScore W2057115306C150194340 @default.
• W2057115306 hasConceptScore W2057115306C150425827 @default.
• W2057115306 hasConceptScore W2057115306C153911025 @default.
• W2057115306 hasConceptScore W2057115306C190727270 @default.
• W2057115306 hasConceptScore W2057115306C22709980 @default.
• W2057115306 hasConceptScore W2057115306C2776745794 @default.
• W2057115306 hasConceptScore W2057115306C552990157 @default.
• W2057115306 hasConceptScore W2057115306C55493867 @default.
• W2057115306 hasConceptScore W2057115306C56428682 @default.
• W2057115306 hasConceptScore W2057115306C64927066 @default.
• W2057115306 hasConceptScore W2057115306C83640560 @default.
• W2057115306 hasConceptScore W2057115306C84772758 @default.
• W2057115306 hasConceptScore W2057115306C86803240 @default.
• W2057115306 hasConceptScore W2057115306C95444343 @default.
• W2057115306 hasIssue "23" @default.
• W2057115306 hasLocation W20571153061 @default.

• next