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• W2057125823 startingPage "343" @default.
• W2057125823 abstract "SINEs and LINEs are short and long interspersed retrotransposable elements, respectively, that invade new genomic sites using RNA intermediates. SINEs and LINEs are found in almost all eukaryotes (although not in Saccharomyces cerevisiae) and together account for at least 34% of the human genome. The noncoding SINEs depend on reverse transcriptase and endonuclease functions encoded by partner LINEs. With the completion of many genome sequences, including our own, the database of SINEs and LINEs has taken a great leap forward. The new data pose new questions that can only be answered by detailed studies of the mechanism of retroposition. Current work ranges from the biochemistry of reverse transcription and integration invitro, target site selection in vivo, nucleocytoplasmic transport of the RNA and ribonucleoprotein intermediates, and mechanisms of genomic turnover. Two particularly exciting new ideas are that SINEs may help cells survive physiological stress, and that the evolution of SINEs and LINEs has been shaped by the forces of RNA interference. Taken together, these studies promise to explain the birth and death of SINEs and LINEs, and the contribution of these repetitive sequence families to the evolution of genomes." @default.
• W2057125823 created "2016-06-24" @default.
• W2057125823 creator A5051683145 @default.
• W2057125823 date "2002-06-01" @default.
• W2057125823 modified "2023-10-03" @default.
• W2057125823 title "SINEs and LINEs: the art of biting the hand that feeds you" @default.
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• W2057125823 doi "https://doi.org/10.1016/s0955-0674(02)00338-1" @default.
• W2057125823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12067657" @default.
• W2057125823 hasPublicationYear "2002" @default.
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