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- W2057127955 abstract "Purpose of review This review aims to illustrate why urea recycling may play an important role in potassium (K+) excretion and to emphasize its potential clinical implications. Recent findings A quantitative analysis of the process of intrarenal urea recycling reveals that the amount of urea delivered to the distal convoluted tubule is about two-fold larger than the quantity of urea excreted in the urine. As the number of osmoles delivered to the late cortical distal nephron (CCD) determines its flow rate when aquaporin 2 water channels have been inserted in the luminal membrane of principal cells, urea recycling may play an important role in regulating the rate of excretion of K+ when the distal delivery of electrolytes is not very high. Summary Urea recycling aids the excretion of K+; this is especially important in patients with disorders or those who are taking drugs that lead to a less lumen-negative voltage in the CCD. As a large quantity of urea is reabsorbed daily in the inner medullary collecting duct, the assumption made in the calculation of the transtubular K concentration gradient that there is no appreciable reabsorption of osmoles downstream CCD is not valid." @default.
- W2057127955 created "2016-06-24" @default.
- W2057127955 creator A5029714963 @default.
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- W2057127955 date "2011-09-01" @default.
- W2057127955 modified "2023-10-11" @default.
- W2057127955 title "Intrarenal urea recycling leads to a higher rate of renal excretion of potassium" @default.
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- W2057127955 doi "https://doi.org/10.1097/mnh.0b013e328349b8f9" @default.
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