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- W2057129148 abstract "Neural tube closure takes place during early embryogenesis and requires interactions between genetic and environmental factors. Failure of neural tube closure is a common congenital malformation that results in morbidity and mortality. A major clinical achievement has been the use of periconceptional folic acid supplements, which prevents approximately 50-75% of cases of neural tube defects. However, the mechanism underlying the beneficial effects of folic acid is far from clear. Biochemical, genetic and epidemiological observations have led to the development of the methylation hypothesis, which suggests that folic acid prevents neural tube defects by stimulating cellular methylation reactions. Exploring the methylation hypothesis could direct us towards additional strategies to prevent neural tube defects." @default.
- W2057129148 created "2016-06-24" @default.
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- W2057129148 date "2006-09-01" @default.
- W2057129148 modified "2023-10-03" @default.
- W2057129148 title "Neural tube defects and folate: case far from closed" @default.
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- W2057129148 doi "https://doi.org/10.1038/nrn1986" @default.
- W2057129148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2970514" @default.
- W2057129148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16924261" @default.
- W2057129148 hasPublicationYear "2006" @default.