FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057132693> ?p ?o ?g. }

• W2057132693 endingPage "9665" @default.
• W2057132693 startingPage "9658" @default.
• W2057132693 abstract "Abstract The breast cancer susceptibility gene BRCA1 encodes a large protein thought to contribute to a variety of cellular processes, although the critical determinants of BRCA1-deficient tumorigenesis remain unclear. Given that BRCA1 is required for cell proliferation, suppressor mutations are believed to modify BRCA1 phenotypes and contribute to the etiology of BRCA1-deficient tumors. Here, we show that overexpression of the homologous recombinase RAD51 in a DT40 BRCA1Δ/Δ mutant rescues defects in proliferation, DNA damage survival, and homologous recombination (HR). In addition, epistasis analysis with BRCA1 and the DNA end-joining factor KU70 indicates that these factors operate independently of one another to repair double-strand breaks. Consistent with this genetic finding, cell synchronization studies show that the ability of BRCA1 to promote radioresistance is restricted to the late S and G2 phases of the cell cycle, as predicted for genes whose function is specific to homology-mediated repair rather than nonhomologous end-joining. Notably, retrospective analyses of microarray expression data reveal elevated expression of RAD51 and two of its late-acting cofactors, RAD54 and RAD51AP1, in BRCA1-deficient versus sporadic breast tumors. Taken together, our results indicate that up-regulation of HR provides a permissive genetic context for cells lacking BRCA1 function by circumventing its requirement in RAD51 subnuclear assembly. Furthermore, the data support a model in which enhanced HR activity contributes to the etiology of BRCA1-deficient tumors. [Cancer Res 2007;67(20):9658–65]" @default.
• W2057132693 created "2016-06-24" @default.
• W2057132693 creator A5001045676 @default.
• W2057132693 creator A5033818746 @default.
• W2057132693 creator A5035688309 @default.
• W2057132693 creator A5075651833 @default.
• W2057132693 creator A5083041672 @default.
• W2057132693 creator A5090259280 @default.
• W2057132693 date "2007-10-15" @default.
• W2057132693 modified "2023-09-30" @default.
• W2057132693 title "RAD51 Up-regulation Bypasses <i>BRCA1</i> Function and Is a Common Feature of <i>BRCA1</i>-Deficient Breast Tumors" @default.
• W2057132693 cites W1540427327 @default.
• W2057132693 cites W1591147683 @default.
• W2057132693 cites W1969150779 @default.
• W2057132693 cites W1972710550 @default.
• W2057132693 cites W1973268287 @default.
• W2057132693 cites W1976960697 @default.
• W2057132693 cites W2003755228 @default.
• W2057132693 cites W2005284058 @default.
• W2057132693 cites W2010845229 @default.
• W2057132693 cites W2017896723 @default.
• W2057132693 cites W2020007184 @default.
• W2057132693 cites W2024342001 @default.
• W2057132693 cites W2030639168 @default.
• W2057132693 cites W2038275315 @default.
• W2057132693 cites W2039435798 @default.
• W2057132693 cites W2046136351 @default.
• W2057132693 cites W2047460928 @default.
• W2057132693 cites W2049820772 @default.
• W2057132693 cites W2053822327 @default.
• W2057132693 cites W2057949133 @default.
• W2057132693 cites W2058800908 @default.
• W2057132693 cites W2059365987 @default.
• W2057132693 cites W2065777930 @default.
• W2057132693 cites W2066108933 @default.
• W2057132693 cites W2066872364 @default.
• W2057132693 cites W2066969492 @default.
• W2057132693 cites W2068087390 @default.
• W2057132693 cites W2068681382 @default.
• W2057132693 cites W2072150230 @default.
• W2057132693 cites W2072981858 @default.
• W2057132693 cites W2082411289 @default.
• W2057132693 cites W2084491471 @default.
• W2057132693 cites W2086449675 @default.
• W2057132693 cites W2087025655 @default.
• W2057132693 cites W2087633346 @default.
• W2057132693 cites W2088179903 @default.
• W2057132693 cites W2105712639 @default.
• W2057132693 cites W2118413367 @default.
• W2057132693 cites W2119999819 @default.
• W2057132693 cites W2121887331 @default.
• W2057132693 cites W2122115679 @default.
• W2057132693 cites W2124357515 @default.
• W2057132693 cites W2128370098 @default.
• W2057132693 cites W2128985829 @default.
• W2057132693 cites W2130447102 @default.
• W2057132693 cites W2142729720 @default.
• W2057132693 cites W2150414518 @default.
• W2057132693 cites W2157269460 @default.
• W2057132693 cites W2157840751 @default.
• W2057132693 cites W2164458581 @default.
• W2057132693 cites W2168225429 @default.
• W2057132693 cites W2169965735 @default.
• W2057132693 cites W2319607989 @default.
• W2057132693 cites W2331372577 @default.
• W2057132693 cites W4241697987 @default.
• W2057132693 doi "https://doi.org/10.1158/0008-5472.can-07-0290" @default.
• W2057132693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17942895" @default.
• W2057132693 hasPublicationYear "2007" @default.
• W2057132693 type Work @default.
• W2057132693 sameAs 2057132693 @default.
• W2057132693 citedByCount "151" @default.
• W2057132693 countsByYear W20571326932012 @default.
• W2057132693 countsByYear W20571326932013 @default.
• W2057132693 countsByYear W20571326932014 @default.
• W2057132693 countsByYear W20571326932015 @default.
• W2057132693 countsByYear W20571326932016 @default.
• W2057132693 countsByYear W20571326932017 @default.
• W2057132693 countsByYear W20571326932018 @default.
• W2057132693 countsByYear W20571326932019 @default.
• W2057132693 countsByYear W20571326932020 @default.
• W2057132693 countsByYear W20571326932021 @default.
• W2057132693 countsByYear W20571326932022 @default.
• W2057132693 countsByYear W20571326932023 @default.
• W2057132693 crossrefType "journal-article" @default.
• W2057132693 hasAuthorship W2057132693A5001045676 @default.
• W2057132693 hasAuthorship W2057132693A5033818746 @default.
• W2057132693 hasAuthorship W2057132693A5035688309 @default.
• W2057132693 hasAuthorship W2057132693A5075651833 @default.
• W2057132693 hasAuthorship W2057132693A5083041672 @default.
• W2057132693 hasAuthorship W2057132693A5090259280 @default.
• W2057132693 hasBestOaLocation W20571326932 @default.
• W2057132693 hasConcept C102744134 @default.
• W2057132693 hasConcept C104317684 @default.
• W2057132693 hasConcept C121608353 @default.
• W2057132693 hasConcept C134935766 @default.
• W2057132693 hasConcept C143425029 @default.
• W2057132693 hasConcept C2778502085 @default.

• next