Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057134443> ?p ?o ?g. }
- W2057134443 endingPage "116" @default.
- W2057134443 startingPage "107" @default.
- W2057134443 abstract "Mammalian females are endowed with a finite number of primordial follicles at birth or shortly thereafter. Immediately following the formation of the primordial follicle pool, cohorts of these follicles are recruited to begin growth, and this recruitment continues until the primordial follicle population is depleted. Once recruited, a follicle will either grow and ovulate or undergo atresia. Follicle atresia results from the apoptotic death of follicular cells. Members of the BCL-2 family of proteins are important regulators of apoptosis in most cells including in the ovary. Here, we tested the hypothesis that the proapoptotic BAX is an important regulator of follicle survival. We used a variety of histological and biochemical techniques to investigate the impact of Bax deletion on follicle growth and death. We observed that the Bax deletion results in delayed vaginal opening and altered follicular growth. Young adult Bax -deficient ovaries contained increased numbers of primordial follicles and a trend towards reduced numbers of growing follicles. Bax deficiency led to a reduction in average litter size, and also a reduction in the number of oocytes ovulated in response to exogenous gonadotropins. In contrast, Bax deficiency did not alter follicle atresia. In conclusion, BAX appears to be an important regulator of follicle growth, but is dispensable for follicle atresia in mice." @default.
- W2057134443 created "2016-06-24" @default.
- W2057134443 creator A5026118897 @default.
- W2057134443 creator A5033063162 @default.
- W2057134443 creator A5040949438 @default.
- W2057134443 creator A5053625755 @default.
- W2057134443 creator A5089585853 @default.
- W2057134443 creator A5091165459 @default.
- W2057134443 date "2007-01-01" @default.
- W2057134443 modified "2023-09-25" @default.
- W2057134443 title "BAX is involved in regulating follicular growth, but is dispensable for follicle atresia in adult mouse ovaries" @default.
- W2057134443 cites W1534163224 @default.
- W2057134443 cites W1546537221 @default.
- W2057134443 cites W1577859676 @default.
- W2057134443 cites W1967999114 @default.
- W2057134443 cites W1970315882 @default.
- W2057134443 cites W1977401380 @default.
- W2057134443 cites W1984547206 @default.
- W2057134443 cites W1996634627 @default.
- W2057134443 cites W2000529918 @default.
- W2057134443 cites W2008597649 @default.
- W2057134443 cites W2018831893 @default.
- W2057134443 cites W2021121648 @default.
- W2057134443 cites W2026105521 @default.
- W2057134443 cites W2029279125 @default.
- W2057134443 cites W2038598495 @default.
- W2057134443 cites W2047247552 @default.
- W2057134443 cites W2048427763 @default.
- W2057134443 cites W2060702385 @default.
- W2057134443 cites W2066275626 @default.
- W2057134443 cites W2067508349 @default.
- W2057134443 cites W2069579599 @default.
- W2057134443 cites W2082302110 @default.
- W2057134443 cites W2086778634 @default.
- W2057134443 cites W2092224562 @default.
- W2057134443 cites W2100468765 @default.
- W2057134443 cites W2107859844 @default.
- W2057134443 cites W2109680952 @default.
- W2057134443 cites W2115183068 @default.
- W2057134443 cites W2117503244 @default.
- W2057134443 cites W2120639484 @default.
- W2057134443 cites W2125739408 @default.
- W2057134443 cites W2131121054 @default.
- W2057134443 cites W2138154085 @default.
- W2057134443 cites W2140698430 @default.
- W2057134443 cites W2145835300 @default.
- W2057134443 cites W2152046955 @default.
- W2057134443 cites W2158102086 @default.
- W2057134443 cites W2165473234 @default.
- W2057134443 cites W2166601968 @default.
- W2057134443 cites W2167187817 @default.
- W2057134443 cites W2167723921 @default.
- W2057134443 cites W2168309922 @default.
- W2057134443 cites W4230268220 @default.
- W2057134443 cites W4234792992 @default.
- W2057134443 cites W4236422495 @default.
- W2057134443 cites W4236935165 @default.
- W2057134443 cites W4237310510 @default.
- W2057134443 cites W4240618231 @default.
- W2057134443 cites W4245299204 @default.
- W2057134443 cites W4253750046 @default.
- W2057134443 cites W4254591796 @default.
- W2057134443 cites W4255861653 @default.
- W2057134443 doi "https://doi.org/10.1530/rep-06-0144" @default.
- W2057134443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17244737" @default.
- W2057134443 hasPublicationYear "2007" @default.
- W2057134443 type Work @default.
- W2057134443 sameAs 2057134443 @default.
- W2057134443 citedByCount "41" @default.
- W2057134443 countsByYear W20571344432012 @default.
- W2057134443 countsByYear W20571344432013 @default.
- W2057134443 countsByYear W20571344432014 @default.
- W2057134443 countsByYear W20571344432015 @default.
- W2057134443 countsByYear W20571344432016 @default.
- W2057134443 countsByYear W20571344432018 @default.
- W2057134443 countsByYear W20571344432019 @default.
- W2057134443 countsByYear W20571344432020 @default.
- W2057134443 countsByYear W20571344432021 @default.
- W2057134443 countsByYear W20571344432022 @default.
- W2057134443 countsByYear W20571344432023 @default.
- W2057134443 crossrefType "journal-article" @default.
- W2057134443 hasAuthorship W2057134443A5026118897 @default.
- W2057134443 hasAuthorship W2057134443A5033063162 @default.
- W2057134443 hasAuthorship W2057134443A5040949438 @default.
- W2057134443 hasAuthorship W2057134443A5053625755 @default.
- W2057134443 hasAuthorship W2057134443A5089585853 @default.
- W2057134443 hasAuthorship W2057134443A5091165459 @default.
- W2057134443 hasBestOaLocation W20571344431 @default.
- W2057134443 hasConcept C102570824 @default.
- W2057134443 hasConcept C104317684 @default.
- W2057134443 hasConcept C105702510 @default.
- W2057134443 hasConcept C126322002 @default.
- W2057134443 hasConcept C134018914 @default.
- W2057134443 hasConcept C16685009 @default.
- W2057134443 hasConcept C187785154 @default.
- W2057134443 hasConcept C190283241 @default.
- W2057134443 hasConcept C196843134 @default.
- W2057134443 hasConcept C2777216303 @default.