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• W2057142015 abstract "Abstract Aim: To externally validate and update a previously developed rule for predicting the presence of serious bacterial infections in children with fever without apparent source. Methods: Patients, 1–36 mo, presenting with fever without source, were prospectively enrolled. Serious bacterial infection included bacterial meningitis, sepsis, bacteraemia, pneumonia, urinary tract infection, bacterial gastroenteritis, osteomyelitis/ethmoiditis. The generalizability of the original rule was determined. Subsequently, the prediction rule was updated using all available data of the patients with fever without source (1996–1998 and 2000–2001, n = 381) using multivariable logistic regression. Results: the generalizability of the rule appeared insufficient in the new patients (n = 150). In the updated rule, independent predictors from history and examination were duration of fever, vomiting, ill clinical appearance, chest‐wall retractions and poor peripheral circulation (ROC area (95%CI): 0.69 (0.63–0.75)). Additional independent predictors from laboratory were serum white blood cell count and C‐reactive protein, and in urinalysis ≥70 white bloods (ROC area (95%CI): 0.83 (0.78–0.88). Conclusions: A previously developed prediction rule for predicting the presence of serious bacterial infection in children with fever without apparent source was updated. Its clinical score can be used as a first screening tool. Additional laboratory testing may specify the individual risk estimate (range: 4–54%) further." @default.
• W2057142015 created "2016-06-24" @default.
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• W2057142015 date "2006-12-20" @default.
• W2057142015 modified "2023-10-16" @default.
• W2057142015 title "Validating and updating a prediction rule for serious bacterial infection in patients with fever without source" @default.
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• W2057142015 doi "https://doi.org/10.1111/j.1651-2227.2006.00033.x" @default.
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