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- W2057145251 abstract "Sixty-four intravenous pyelograms using varying doses of diatrizoate have been carried out in 39 patients. The subjects investigated represented a wide range of renal function, and this was studied by measuring the glomerular filtration rate by the clearance of 57 Co. vitamin B12. The fate of the contrast medium was followed by means of radioisotope labelling, and findings in plasma and urine have been related to renal function. It has been confirmed that diatrizoate is excreted by glomerular filtration, and that its concentration in the urine is therefore a function of plasma level, glomerular filtration rate, and urine flow rate. Studies on the mechanism of water handling of individuals given a large solute load were carried out, and we suggest that in patients with adequate renal function there is on average no improvement in urinary contrast concentration with doses larger than 1 ml. Urografin 60%/kg. body weight. The increase in urinary concentration achieved by 1 ml. contrast/kg. over ½ ml. contrast/kg. was not statistically significant; attention is drawn to the great variability in dehydration state in the same individual on different days. In patients with impaired renal function, urinary contrast concentrations sufficient to produce useful urograms may be achieved by using up to 2 ml. Urografin 60%/kg. body weight. Sixty-four intravenous pyelograms using varying doses of diatrizoate have been carried out in 39 patients. The subjects investigated represented a wide range of renal function, and this was studied by measuring the glomerular filtration rate by the clearance of 57 Co. vitamin B12. The fate of the contrast medium was followed by means of radioisotope labelling, and findings in plasma and urine have been related to renal function. It has been confirmed that diatrizoate is excreted by glomerular filtration, and that its concentration in the urine is therefore a function of plasma level, glomerular filtration rate, and urine flow rate. Studies on the mechanism of water handling of individuals given a large solute load were carried out, and we suggest that in patients with adequate renal function there is on average no improvement in urinary contrast concentration with doses larger than 1 ml. Urografin 60%/kg. body weight. The increase in urinary concentration achieved by 1 ml. contrast/kg. over ½ ml. contrast/kg. was not statistically significant; attention is drawn to the great variability in dehydration state in the same individual on different days. In patients with impaired renal function, urinary contrast concentrations sufficient to produce useful urograms may be achieved by using up to 2 ml. Urografin 60%/kg. body weight." @default.
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- W2057145251 date "1968-01-01" @default.
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- W2057145251 title "Intravenous urography and renal function" @default.
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- W2057145251 doi "https://doi.org/10.1016/s0009-9260(68)80011-x" @default.
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