Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057154782> ?p ?o ?g. }
- W2057154782 endingPage "8" @default.
- W2057154782 startingPage "1" @default.
- W2057154782 abstract "Experiments show that class switch recombination (CSR) depends on the number of divisions that the cell has performed rather than on the time since stimulation. Using computer simulations of CSR dynamics in B cell populations, we addressed the following questions. How does the probability of CSR depend on the number of divisions that a cell has performed? How does the cell decide which isotype to switch to? Does this decision depend on the distance between the genes of the pre-switch and the post-switch isotype? Our results indicate that post-switch isotype choice may be determined indirectly by the probabilities of division (which is fixed) and of switching per division (which increases as a function of the number of divisions that a cell performs), and more directly by a bias in the choice of the post-switch C gene segment towards those proximal to the pre-switch C gene." @default.
- W2057154782 created "2016-06-24" @default.
- W2057154782 creator A5076001110 @default.
- W2057154782 date "2000-04-01" @default.
- W2057154782 modified "2023-09-25" @default.
- W2057154782 title "Immunoglobulin Class Switch Recombination Machinery: Progress and Challenges" @default.
- W2057154782 cites W107818682 @default.
- W2057154782 cites W1495338298 @default.
- W2057154782 cites W1500511287 @default.
- W2057154782 cites W1510434574 @default.
- W2057154782 cites W1515875551 @default.
- W2057154782 cites W1534536451 @default.
- W2057154782 cites W1554669615 @default.
- W2057154782 cites W1574705898 @default.
- W2057154782 cites W1858467446 @default.
- W2057154782 cites W1939573161 @default.
- W2057154782 cites W1968153272 @default.
- W2057154782 cites W1977145510 @default.
- W2057154782 cites W1978174408 @default.
- W2057154782 cites W1985067006 @default.
- W2057154782 cites W1985219773 @default.
- W2057154782 cites W1987850577 @default.
- W2057154782 cites W1993219448 @default.
- W2057154782 cites W2004166886 @default.
- W2057154782 cites W2004911925 @default.
- W2057154782 cites W2016003805 @default.
- W2057154782 cites W2017472400 @default.
- W2057154782 cites W2021959562 @default.
- W2057154782 cites W2031778684 @default.
- W2057154782 cites W2032352554 @default.
- W2057154782 cites W2036277308 @default.
- W2057154782 cites W2044584166 @default.
- W2057154782 cites W2046941856 @default.
- W2057154782 cites W2051115015 @default.
- W2057154782 cites W2053200644 @default.
- W2057154782 cites W2056676744 @default.
- W2057154782 cites W2057628806 @default.
- W2057154782 cites W2063173000 @default.
- W2057154782 cites W2067961064 @default.
- W2057154782 cites W2072930832 @default.
- W2057154782 cites W2073158216 @default.
- W2057154782 cites W2077527504 @default.
- W2057154782 cites W2080795138 @default.
- W2057154782 cites W2081478060 @default.
- W2057154782 cites W2092322132 @default.
- W2057154782 cites W2097736672 @default.
- W2057154782 cites W2101065217 @default.
- W2057154782 cites W2107008702 @default.
- W2057154782 cites W2111941208 @default.
- W2057154782 cites W2117421686 @default.
- W2057154782 cites W2118275859 @default.
- W2057154782 cites W2123196835 @default.
- W2057154782 cites W2124052581 @default.
- W2057154782 cites W2132118906 @default.
- W2057154782 cites W2132714970 @default.
- W2057154782 cites W2134951498 @default.
- W2057154782 cites W2141308574 @default.
- W2057154782 cites W2141326900 @default.
- W2057154782 cites W2154236236 @default.
- W2057154782 cites W2155070012 @default.
- W2057154782 cites W2166520151 @default.
- W2057154782 cites W2168123515 @default.
- W2057154782 cites W344740868 @default.
- W2057154782 cites W4231956741 @default.
- W2057154782 cites W4313331828 @default.
- W2057154782 cites W63754614 @default.
- W2057154782 doi "https://doi.org/10.1006/clim.2000.4848" @default.
- W2057154782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10794426" @default.
- W2057154782 hasPublicationYear "2000" @default.
- W2057154782 type Work @default.
- W2057154782 sameAs 2057154782 @default.
- W2057154782 citedByCount "12" @default.
- W2057154782 crossrefType "journal-article" @default.
- W2057154782 hasAuthorship W2057154782A5076001110 @default.
- W2057154782 hasConcept C104317684 @default.
- W2057154782 hasConcept C137756551 @default.
- W2057154782 hasConcept C14036430 @default.
- W2057154782 hasConcept C1491633281 @default.
- W2057154782 hasConcept C154945302 @default.
- W2057154782 hasConcept C156695909 @default.
- W2057154782 hasConcept C159654299 @default.
- W2057154782 hasConcept C2777212361 @default.
- W2057154782 hasConcept C2777991845 @default.
- W2057154782 hasConcept C2778453870 @default.
- W2057154782 hasConcept C33923547 @default.
- W2057154782 hasConcept C41008148 @default.
- W2057154782 hasConcept C542903549 @default.
- W2057154782 hasConcept C54355233 @default.
- W2057154782 hasConcept C60798267 @default.
- W2057154782 hasConcept C85813293 @default.
- W2057154782 hasConcept C86803240 @default.
- W2057154782 hasConcept C94375191 @default.
- W2057154782 hasConcept C95444343 @default.
- W2057154782 hasConceptScore W2057154782C104317684 @default.
- W2057154782 hasConceptScore W2057154782C137756551 @default.
- W2057154782 hasConceptScore W2057154782C14036430 @default.
- W2057154782 hasConceptScore W2057154782C1491633281 @default.
- W2057154782 hasConceptScore W2057154782C154945302 @default.