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- W2057156659 endingPage "307" @default.
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- W2057156659 abstract "Evidence has accumulated that nonsteroidal anti-inflammatory drugs (NSAIDs) cause clinically important gastroduodenal ulcers. The pathogenesis, which involves the impairment of mucosal resistance to injury in an acid-peptic environment, is multi-actorial and controversial. Ulcers caused by NSAIDs can occur either in mucosa inflamed because of infection with Helicobacter pylori or in histologically normal mucosa. The use of these drugs has been linked to an unexpectedly high incidence of ulcer complications, and a history of peptic ulcer disease is common in such cases. Nonsteroidal anti-inflammatory drugs thus appear both to exacerbate an underlying peptic diathesis and to cause de novo ulcers. The association between the use of these drugs and ulcer complications is supported by ulcer prevalence data from cross-sectional studies, and by data from case-controlled and cohort studies, and from randomized, experimental trials. Drug-induced gastric ulcers have been prevented by misoprostol, but not by H2 blocker therapy. Several therapies have been reported to promote ulcer healing despite continued use of NSAIDs, but adequate controlled trials have not been done. Small gastric and duodenal ulcers readily heal, whereas larger gastric ulcers require vigorous and prolonged therapy. The relative efficacies of various therapies in preventing ulcers, healing ulcers, or preventing complications remain to be established." @default.
- W2057156659 created "2016-06-24" @default.
- W2057156659 creator A5083325211 @default.
- W2057156659 date "1991-02-15" @default.
- W2057156659 modified "2023-10-16" @default.
- W2057156659 title "Nonsteroidal Anti-inflammatory Drugs and Peptic Ulcer Disease" @default.
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- W2057156659 cites W1615012936 @default.
- W2057156659 cites W1678974357 @default.
- W2057156659 cites W1782227555 @default.
- W2057156659 cites W1791264693 @default.
- W2057156659 cites W1812515591 @default.
- W2057156659 cites W1953247191 @default.
- W2057156659 cites W1966155743 @default.
- W2057156659 cites W1966404303 @default.
- W2057156659 cites W1969927128 @default.
- W2057156659 cites W1973269913 @default.
- W2057156659 cites W1973427327 @default.
- W2057156659 cites W1977199711 @default.
- W2057156659 cites W1983664772 @default.
- W2057156659 cites W1988257004 @default.
- W2057156659 cites W1988971545 @default.
- W2057156659 cites W1991844251 @default.
- W2057156659 cites W1995294317 @default.
- W2057156659 cites W1995678228 @default.
- W2057156659 cites W2002738295 @default.
- W2057156659 cites W2002772962 @default.
- W2057156659 cites W2007260789 @default.
- W2057156659 cites W2013553901 @default.
- W2057156659 cites W2015499269 @default.
- W2057156659 cites W2016212870 @default.
- W2057156659 cites W2022399850 @default.
- W2057156659 cites W2033766631 @default.
- W2057156659 cites W2035132069 @default.
- W2057156659 cites W2037914706 @default.
- W2057156659 cites W2039134012 @default.
- W2057156659 cites W2042226397 @default.
- W2057156659 cites W2051691071 @default.
- W2057156659 cites W2056195056 @default.
- W2057156659 cites W2061177039 @default.
- W2057156659 cites W2063365962 @default.
- W2057156659 cites W2063560184 @default.
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- W2057156659 cites W2070091239 @default.
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- W2057156659 cites W2088289437 @default.
- W2057156659 cites W2092711589 @default.
- W2057156659 cites W2094978781 @default.
- W2057156659 cites W2097238265 @default.
- W2057156659 cites W2100123265 @default.
- W2057156659 cites W2101679451 @default.
- W2057156659 cites W2105870750 @default.
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- W2057156659 cites W2117680210 @default.
- W2057156659 cites W2122159614 @default.
- W2057156659 cites W2135066869 @default.
- W2057156659 cites W2143268450 @default.
- W2057156659 cites W2148785361 @default.
- W2057156659 cites W2151667645 @default.
- W2057156659 cites W2163226435 @default.
- W2057156659 cites W2167378024 @default.
- W2057156659 cites W2186004090 @default.
- W2057156659 cites W2275476932 @default.
- W2057156659 cites W2290055592 @default.
- W2057156659 cites W2320705810 @default.
- W2057156659 cites W2330367835 @default.
- W2057156659 cites W2399164204 @default.
- W2057156659 cites W2405670516 @default.
- W2057156659 cites W2406089701 @default.
- W2057156659 cites W2418777565 @default.
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- W2057156659 doi "https://doi.org/10.7326/0003-4819-114-4-307" @default.
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