FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057165152> ?p ?o ?g. }

• W2057165152 endingPage "2485" @default.
• W2057165152 startingPage "2476" @default.
• W2057165152 abstract "Summary Sensory neurons from sickle cell disease mice are sensitized to cold, mirroring behavioral observations, and have increased expression of endothelin 1 and tachykinin receptor 1. Sickle cell disease (SCD) is associated with acute vaso-occlusive crises that trigger painful episodes and frequently involves ongoing, chronic pain. In addition, both humans and mice with SCD experience heightened cold sensitivity. However, studies have not addressed the mechanism(s) underlying the cold sensitization or its progression with age. Here we measured thermotaxis behavior in young and aged mice with severe SCD. Sickle mice had a marked increase in cold sensitivity measured by a cold preference test. Furthermore, cold hypersensitivity worsened with advanced age. We assessed whether enhanced peripheral input contributes to the chronic cold pain behavior by recording from C fibers, many of which are cold sensitive, in skin-nerve preparations. We observed that C fibers from sickle mice displayed a shift to warmer (more sensitive) cold detection thresholds. To address mechanisms underlying the cold sensitization in primary afferent neurons, we quantified mRNA expression levels for ion channels thought to be involved in cold detection. These included the transient receptor potential melastatin 8 (Trpm8) and transient receptor potential ankyrin 1 (Trpa1) channels, as well as the 2-pore domain potassium channels, TREK-1 (Kcnk2), TREK-2 (Kcnk10), and TRAAK (Kcnk4). Surprisingly, transcript expression levels of all of these channels were comparable between sickle and control mice. We further examined transcript expression of 83 additional pain-related genes, and found increased mRNA levels for endothelin 1 and tachykinin receptor 1. These factors may contribute to hypersensitivity in sickle mice at both the afferent and behavioral levels." @default.
• W2057165152 created "2016-06-24" @default.
• W2057165152 creator A5021731392 @default.
• W2057165152 creator A5037057235 @default.
• W2057165152 creator A5078351705 @default.
• W2057165152 creator A5088325043 @default.
• W2057165152 date "2014-12-01" @default.
• W2057165152 modified "2023-10-14" @default.
• W2057165152 title "Cold hypersensitivity increases with age in mice with sickle cell disease" @default.
• W2057165152 cites W1509243631 @default.
• W2057165152 cites W1526630390 @default.
• W2057165152 cites W1605804992 @default.
• W2057165152 cites W1678824425 @default.
• W2057165152 cites W1815264282 @default.
• W2057165152 cites W1827174692 @default.
• W2057165152 cites W1963871181 @default.
• W2057165152 cites W1975332997 @default.
• W2057165152 cites W1975338458 @default.
• W2057165152 cites W1977708103 @default.
• W2057165152 cites W1977863235 @default.
• W2057165152 cites W1984607602 @default.
• W2057165152 cites W1986885145 @default.
• W2057165152 cites W1987958749 @default.
• W2057165152 cites W1988635342 @default.
• W2057165152 cites W1993085847 @default.
• W2057165152 cites W1995330222 @default.
• W2057165152 cites W1995423921 @default.
• W2057165152 cites W1998467441 @default.
• W2057165152 cites W2003963645 @default.
• W2057165152 cites W2007055803 @default.
• W2057165152 cites W2007503767 @default.
• W2057165152 cites W2009967312 @default.
• W2057165152 cites W2010349930 @default.
• W2057165152 cites W2012769487 @default.
• W2057165152 cites W2016237453 @default.
• W2057165152 cites W2022386219 @default.
• W2057165152 cites W2032965948 @default.
• W2057165152 cites W2033626184 @default.
• W2057165152 cites W2035876173 @default.
• W2057165152 cites W2039463240 @default.
• W2057165152 cites W2040708681 @default.
• W2057165152 cites W2043088091 @default.
• W2057165152 cites W2043293474 @default.
• W2057165152 cites W2045072647 @default.
• W2057165152 cites W2047225851 @default.
• W2057165152 cites W2048922834 @default.
• W2057165152 cites W2058793021 @default.
• W2057165152 cites W2058808922 @default.
• W2057165152 cites W2061599979 @default.
• W2057165152 cites W2071276645 @default.
• W2057165152 cites W2074027763 @default.
• W2057165152 cites W2077154875 @default.
• W2057165152 cites W2080410552 @default.
• W2057165152 cites W2092610649 @default.
• W2057165152 cites W2096553125 @default.
• W2057165152 cites W2099639317 @default.
• W2057165152 cites W2107057154 @default.
• W2057165152 cites W2109879418 @default.
• W2057165152 cites W2120229762 @default.
• W2057165152 cites W2127265286 @default.
• W2057165152 cites W2145981101 @default.
• W2057165152 cites W2156733405 @default.
• W2057165152 cites W2156965630 @default.
• W2057165152 cites W2157250445 @default.
• W2057165152 cites W2157761253 @default.
• W2057165152 cites W2342370314 @default.
• W2057165152 cites W47071877 @default.
• W2057165152 cites W965296396 @default.
• W2057165152 doi "https://doi.org/10.1016/j.pain.2014.05.030" @default.
• W2057165152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4250326" @default.
• W2057165152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24953902" @default.
• W2057165152 hasPublicationYear "2014" @default.
• W2057165152 type Work @default.
• W2057165152 sameAs 2057165152 @default.
• W2057165152 citedByCount "53" @default.
• W2057165152 countsByYear W20571651522014 @default.
• W2057165152 countsByYear W20571651522015 @default.
• W2057165152 countsByYear W20571651522016 @default.
• W2057165152 countsByYear W20571651522017 @default.
• W2057165152 countsByYear W20571651522018 @default.
• W2057165152 countsByYear W20571651522019 @default.
• W2057165152 countsByYear W20571651522020 @default.
• W2057165152 countsByYear W20571651522021 @default.
• W2057165152 countsByYear W20571651522022 @default.
• W2057165152 countsByYear W20571651522023 @default.
• W2057165152 crossrefType "journal-article" @default.
• W2057165152 hasAuthorship W2057165152A5021731392 @default.
• W2057165152 hasAuthorship W2057165152A5037057235 @default.
• W2057165152 hasAuthorship W2057165152A5078351705 @default.
• W2057165152 hasAuthorship W2057165152A5088325043 @default.
• W2057165152 hasBestOaLocation W20571651522 @default.
• W2057165152 hasConcept C104317684 @default.
• W2057165152 hasConcept C126322002 @default.
• W2057165152 hasConcept C134018914 @default.
• W2057165152 hasConcept C143065580 @default.
• W2057165152 hasConcept C144980905 @default.
• W2057165152 hasConcept C15490471 @default.
• W2057165152 hasConcept C155164980 @default.

• next