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• W2057165798 abstract "Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative diseases that overlap clinically, genetically, and pathologically. Dysregulation of fused in sarcoma (FUS) has been hypothesized to cause ALS and FTLD in gain-of-function and/or loss-of-function manners. However, the link between the pathogenesis of ALS/FTLD and dysfunction of FUS has not been clearly determined. In this study, we found that overexpression of FUS, but not knocking-down of endogenous FUS expression, induces death in motor neuronal NSC34 cells and primary cortical neurons via the mitochondrial apoptotic pathway, possibly independently of transactive response DNA-binding protein-43. Furthermore, we found that nuclear FUS, but not cytoplasmic FUS, is responsible for FUS-induced neuronal cell death. These observations suggest that the gain-of-function of FUS in the nucleus contributes to the pathogenesis of FUS-linked neurodegenerative diseases." @default.
• W2057165798 created "2016-06-24" @default.
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• W2057165798 creator A5020459661 @default.
• W2057165798 date "2015-02-01" @default.
• W2057165798 modified "2023-10-16" @default.
• W2057165798 title "Overexpression of nuclear FUS induces neuronal cell death" @default.
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• W2057165798 doi "https://doi.org/10.1016/j.neuroscience.2014.12.007" @default.
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