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- W2057173327 abstract "NTP-motif, a consensus sequence previously shown to be characteristic of numerous NTP-utilizing enzymes, was identified in nonstructural proteins of several groups of positive-strand RNA viruses. These groups include picorna-, alpha-, and coronaviruses infecting animals and como-, poty-, tobamo-, tricorna-, hordei-, and furoviruses of plants, totalling 21 viruses. It has been demonstrated that the viral NTP-motif-containing proteins constitute three distinct families, the sequences within each family being similar to each other at a statistically highly significant level. A lower, but still valid similarity has also been revealed between the families. An overall alignment has been generated, which includes several highly conserved sequence stretches. The two most prominent of the latter contain the socalled “A” and “B” sites of the NTP-motif, with four of the five invariant amino acid residues observed within these sequences. These observations, taken together with the results of comparative analysis of the positions occupied by respective proteins (domains) in viral multidomain proteins, suggest that all the NTP-motif-containing proteins of positive-strand RNA viruses are homologous, constituting a highly diverged monophyletic group. In this group the “A” and “B” sites of the NTP-motif are the most conserved sequences and, by inference, should play the principal role in the functioning of the proteins. A hypothesis is proposed that all these proteins posses NTP-binding capacity and possibly NTPase activity, performing some NTP-dependent function in viral RNA replication. The importance of phylogenetic analysis for the assessment of the significance of the occurrence of the NTP-motif (and of sequence motifs of this sort in general) in proteins is emphasized." @default.
- W2057173327 created "2016-06-24" @default.
- W2057173327 creator A5035240489 @default.
- W2057173327 creator A5038215233 @default.
- W2057173327 creator A5056215953 @default.
- W2057173327 creator A5091096445 @default.
- W2057173327 date "1989-03-01" @default.
- W2057173327 modified "2023-09-27" @default.
- W2057173327 title "An NTP-binding motif is the most conserved sequence in a highly diverged monophyletic group of proteins involved in positive strand RNA viral replication" @default.
- W2057173327 cites W124504601 @default.
- W2057173327 cites W1499426087 @default.
- W2057173327 cites W1518942907 @default.
- W2057173327 cites W1528509576 @default.
- W2057173327 cites W1532353118 @default.
- W2057173327 cites W1573694969 @default.
- W2057173327 cites W1590469538 @default.
- W2057173327 cites W1730064184 @default.
- W2057173327 cites W1921765205 @default.
- W2057173327 cites W1966193664 @default.
- W2057173327 cites W1973928866 @default.
- W2057173327 cites W1981153502 @default.
- W2057173327 cites W1983157624 @default.
- W2057173327 cites W1984848917 @default.
- W2057173327 cites W1989929072 @default.
- W2057173327 cites W1992616140 @default.
- W2057173327 cites W1994193749 @default.
- W2057173327 cites W1995981593 @default.
- W2057173327 cites W1996180485 @default.
- W2057173327 cites W1997497266 @default.
- W2057173327 cites W2003633983 @default.
- W2057173327 cites W2005313213 @default.
- W2057173327 cites W2008269336 @default.
- W2057173327 cites W2009785322 @default.
- W2057173327 cites W2013540958 @default.
- W2057173327 cites W2020515594 @default.
- W2057173327 cites W2021947220 @default.
- W2057173327 cites W2024826894 @default.
- W2057173327 cites W2026066831 @default.
- W2057173327 cites W2027513600 @default.
- W2057173327 cites W2027598863 @default.
- W2057173327 cites W2032676385 @default.
- W2057173327 cites W2032705991 @default.
- W2057173327 cites W2037720398 @default.
- W2057173327 cites W2039358467 @default.
- W2057173327 cites W2039759921 @default.
- W2057173327 cites W2044524906 @default.
- W2057173327 cites W2044966609 @default.
- W2057173327 cites W2047730886 @default.
- W2057173327 cites W2049449836 @default.
- W2057173327 cites W2055319302 @default.
- W2057173327 cites W2056620767 @default.
- W2057173327 cites W2061746749 @default.
- W2057173327 cites W2070008410 @default.
- W2057173327 cites W2074086678 @default.
- W2057173327 cites W2076152771 @default.
- W2057173327 cites W2080192346 @default.
- W2057173327 cites W2081231862 @default.
- W2057173327 cites W2081615539 @default.
- W2057173327 cites W2083188919 @default.
- W2057173327 cites W2084554884 @default.
- W2057173327 cites W2086937185 @default.
- W2057173327 cites W2088536392 @default.
- W2057173327 cites W2091985164 @default.
- W2057173327 cites W2093176488 @default.
- W2057173327 cites W2094816576 @default.
- W2057173327 cites W2097280591 @default.
- W2057173327 cites W2100256775 @default.
- W2057173327 cites W2101464105 @default.
- W2057173327 cites W2114323557 @default.
- W2057173327 cites W2117708081 @default.
- W2057173327 cites W2122323540 @default.
- W2057173327 cites W2129090607 @default.
- W2057173327 cites W2143948512 @default.
- W2057173327 cites W2153712534 @default.
- W2057173327 cites W2157707773 @default.
- W2057173327 cites W2158273734 @default.
- W2057173327 cites W2161454881 @default.
- W2057173327 cites W2230298622 @default.
- W2057173327 cites W2271264493 @default.
- W2057173327 cites W2419034964 @default.
- W2057173327 cites W2918035219 @default.
- W2057173327 cites W4205722384 @default.
- W2057173327 cites W4241746360 @default.
- W2057173327 doi "https://doi.org/10.1007/bf02102483" @default.
- W2057173327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7087505" @default.
- W2057173327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2522556" @default.
- W2057173327 hasPublicationYear "1989" @default.
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