FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057180183> ?p ?o ?g. }

• W2057180183 endingPage "3154" @default.
• W2057180183 startingPage "3143" @default.
• W2057180183 abstract "As a metabolic sensor, the serine/threonine protein kinase AMP-activated protein kinase (AMPK) promotes the adaptation of cells to signals arising from nutrients, hormones, and growth factors. The ability of IGF-I to stimulate protein synthesis is suppressed by AMPK, therefore, these studies were undertaken to determine whether IGF-I modulates AMPK activity. IGF-I dose-dependently suppressed phosphorylation of AMPK T172, and it stimulated AMPK S485 phosphorylation in vascular smooth muscle cells (VSMC). To determine whether stimulation of AMPK S485 phosphorylation was mediating this response, VSMC were transduced with a mutant AMPKα (AMPK S485A). Expression of this altered form inhibited the ability of IGF-I to suppress AMPK T172 activation, which resulted in inhibition of IGF-I-stimulated phosphorylation of P70S6 kinase. In contrast, expression of an AMPK S485D mutant resulted in constitutive suppression of AMPK activity and was associated with increased IGF-I-stimulated P70S6K phosphorylation and protein synthesis. The addition of a specific AKT inhibitor or expression of an AKT1 short hairpin RNA inhibited AMPK S485 phosphorylation, and it attenuated the IGF-I-induced decrease in AMPK T172 phosphorylation. Exposure to high glucose concentrations suppressed AMPK activity and stimulated S485 phosphorylation, and IGF-I stimulated a further increase in S485 phosphorylation and AMPK T172 suppression. We conclude that AMPK S485 phosphorylation negatively regulates AMPK activity by modulating the T172 phosphorylation response to high glucose and IGF-I. IGF-I stimulates S485 phosphorylation through AKT1. The results suggest that AMPK plays an inhibitory role in modulating IGF-I-stimulated protein synthesis and that IGF-I must down-regulate AMPK activity to induce an optimal anabolic response." @default.
• W2057180183 created "2016-06-24" @default.
• W2057180183 creator A5000288481 @default.
• W2057180183 creator A5048398884 @default.
• W2057180183 creator A5067213698 @default.
• W2057180183 date "2011-06-14" @default.
• W2057180183 modified "2023-10-18" @default.
• W2057180183 title "Suppression of AMPK Activation via S485 Phosphorylation by IGF-I during Hyperglycemia Is Mediated by AKT Activation in Vascular Smooth Muscle Cells" @default.
• W2057180183 cites W1563676220 @default.
• W2057180183 cites W1963664301 @default.
• W2057180183 cites W1975303892 @default.
• W2057180183 cites W1987945927 @default.
• W2057180183 cites W1992304595 @default.
• W2057180183 cites W1999580131 @default.
• W2057180183 cites W2001568034 @default.
• W2057180183 cites W2007477376 @default.
• W2057180183 cites W2021724668 @default.
• W2057180183 cites W2024929104 @default.
• W2057180183 cites W2033473463 @default.
• W2057180183 cites W2035831225 @default.
• W2057180183 cites W2050908283 @default.
• W2057180183 cites W2053213876 @default.
• W2057180183 cites W2060818930 @default.
• W2057180183 cites W2060890640 @default.
• W2057180183 cites W2065671662 @default.
• W2057180183 cites W2094719535 @default.
• W2057180183 cites W2099704543 @default.
• W2057180183 cites W2101428185 @default.
• W2057180183 cites W2101579411 @default.
• W2057180183 cites W2101677747 @default.
• W2057180183 cites W2103198329 @default.
• W2057180183 cites W2104878828 @default.
• W2057180183 cites W2105746834 @default.
• W2057180183 cites W2108103966 @default.
• W2057180183 cites W2109840033 @default.
• W2057180183 cites W2111144663 @default.
• W2057180183 cites W2111568746 @default.
• W2057180183 cites W2112059696 @default.
• W2057180183 cites W2113517766 @default.
• W2057180183 cites W2117275311 @default.
• W2057180183 cites W2121254343 @default.
• W2057180183 cites W2124562777 @default.
• W2057180183 cites W2137739571 @default.
• W2057180183 cites W2139143788 @default.
• W2057180183 cites W2140725006 @default.
• W2057180183 cites W2142191437 @default.
• W2057180183 cites W2147594695 @default.
• W2057180183 cites W2149785020 @default.
• W2057180183 cites W2155598285 @default.
• W2057180183 cites W2162103674 @default.
• W2057180183 cites W2166500288 @default.
• W2057180183 cites W2166978593 @default.
• W2057180183 cites W2170704593 @default.
• W2057180183 doi "https://doi.org/10.1210/en.2011-0155" @default.
• W2057180183 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3138225" @default.
• W2057180183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21673100" @default.
• W2057180183 hasPublicationYear "2011" @default.
• W2057180183 type Work @default.
• W2057180183 sameAs 2057180183 @default.
• W2057180183 citedByCount "100" @default.
• W2057180183 countsByYear W20571801832012 @default.
• W2057180183 countsByYear W20571801832013 @default.
• W2057180183 countsByYear W20571801832014 @default.
• W2057180183 countsByYear W20571801832015 @default.
• W2057180183 countsByYear W20571801832016 @default.
• W2057180183 countsByYear W20571801832017 @default.
• W2057180183 countsByYear W20571801832018 @default.
• W2057180183 countsByYear W20571801832019 @default.
• W2057180183 countsByYear W20571801832020 @default.
• W2057180183 countsByYear W20571801832021 @default.
• W2057180183 countsByYear W20571801832022 @default.
• W2057180183 countsByYear W20571801832023 @default.
• W2057180183 crossrefType "journal-article" @default.
• W2057180183 hasAuthorship W2057180183A5000288481 @default.
• W2057180183 hasAuthorship W2057180183A5048398884 @default.
• W2057180183 hasAuthorship W2057180183A5067213698 @default.
• W2057180183 hasBestOaLocation W20571801831 @default.
• W2057180183 hasConcept C11960822 @default.
• W2057180183 hasConcept C126322002 @default.
• W2057180183 hasConcept C134018914 @default.
• W2057180183 hasConcept C185592680 @default.
• W2057180183 hasConcept C2776780712 @default.
• W2057180183 hasConcept C2780124434 @default.
• W2057180183 hasConcept C71924100 @default.
• W2057180183 hasConcept C75217442 @default.
• W2057180183 hasConcept C86803240 @default.
• W2057180183 hasConcept C95444343 @default.
• W2057180183 hasConcept C97029542 @default.
• W2057180183 hasConceptScore W2057180183C11960822 @default.
• W2057180183 hasConceptScore W2057180183C126322002 @default.
• W2057180183 hasConceptScore W2057180183C134018914 @default.
• W2057180183 hasConceptScore W2057180183C185592680 @default.
• W2057180183 hasConceptScore W2057180183C2776780712 @default.
• W2057180183 hasConceptScore W2057180183C2780124434 @default.
• W2057180183 hasConceptScore W2057180183C71924100 @default.
• W2057180183 hasConceptScore W2057180183C75217442 @default.
• W2057180183 hasConceptScore W2057180183C86803240 @default.
• W2057180183 hasConceptScore W2057180183C95444343 @default.

• next