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- W2057181485 abstract "To identify the possible regulatory sequences in the genetic expression of fibrinogen, a human genomic DNA library raised in λEHBL 4 phage was screened using cDNA probes coding for the Aα, Bβ and γ chains of human fibrinogen. The entire fibrinogen locus was characterized and its organization analysed by means of hybridization and restriction mapping. Among the clones identified, a single recombinant λ phage contained the gene and its 5′-and 3′-flanking regions. A 1.5 kb fragment of the immediate 5′-flanking region was sequenced and S1 mapping experiments revealed three transcription start points. Comparison of this sequence with that previously reported for the same region upstream from the human γ gene revealed no significant homology which suggests that the potential promoting sequences of these genes are different. In contrast, comparison of the 5′-flanking regions of human and rat β genes revealed a 142 bp sequence of 80% homology situated 16 bp upstream from the human gene. This highly conserved region may well represents a potential candidate for a regulatory sequence of the human β gene." @default.
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- W2057181485 date "1987-01-01" @default.
- W2057181485 modified "2023-09-27" @default.
- W2057181485 title "Characterization of the 5′-flanking region for the human fibrinogen β gene" @default.
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- W2057181485 doi "https://doi.org/10.1093/nar/15.4.1615" @default.
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