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• W2057181580 abstract "Angiotensin II is very important in the regulation of blood pressure. This small peptide binds to cell surface receptors, initiating a wide diversity of physiologic responses. There are two major subtypes of angiotensin II receptors referred to as AT₁ and AT₂. In this article we describe the cloning and the biochemical characterization of the AT₁ receptor. Antibodies against this receptor have been used to define its tissue distribution. The AT₁ receptor is a member of the seven transmembrane spanning class of receptors. It initiates a complex series of signaling events, including activation of membrane phospholipases and intracellular kinases. In the human a single AT₁ receptor protein mediates virtually all the effects of angiotensin II, suggesting that tissue specificity of angiotensin II must be due to organ-specific intracellular signaling." @default.
• W2057181580 created "2016-06-24" @default.
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• W2057181580 date "1993-11-01" @default.
• W2057181580 modified "2023-09-28" @default.
• W2057181580 title "The Biology of Angiotensin II Receptors" @default.
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• W2057181580 doi "https://doi.org/10.1016/s0272-6386(12)80441-0" @default.
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