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• W2057182724 endingPage "1733" @default.
• W2057182724 startingPage "1728" @default.
• W2057182724 abstract "Factors that affect naive T cell proliferation in syngeneic lymphopenic hosts were investigated. 2C T cell receptor (TCR) transgenic T cells lacking both CD8 and CD4 survived but hardly proliferated. Proliferation of CD8(+) 2C cells was proportional to the abundance of cognate peptide/MHC complexes and was severely inhibited by injection of anti-CD8 antibody. Weakly reactive self-peptides slightly enhanced CD8(+) 2C cell proliferation whereas a potent agonist peptide promoted much more rapid proliferation, but inflammation-stimulating adjuvant had only a small effect on the rate of cell proliferation. The findings suggest that under uniform lymphopenic conditions, the widely different rates of proliferation of T cells expressing various TCR, or the same TCR in the presence or absence of CD8, reflect the strength of interaction between TCR and MHC associated with particular self-peptides." @default.
• W2057182724 created "2016-06-24" @default.
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• W2057182724 date "2001-02-13" @default.
• W2057182724 modified "2023-09-23" @default.
• W2057182724 title "Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors" @default.
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• W2057182724 doi "https://doi.org/10.1073/pnas.98.4.1728" @default.
• W2057182724 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/29325" @default.
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