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- W2057183661 endingPage "217" @default.
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- W2057183661 abstract "Ecm29 is an ˜200-K HEAT-repeat protein that associates with the 26S proteasome in yeast and HeLa cells. Whereas in most mouse organs Ecm29 is present as a single 200-K protein, in the brain there are eleven species, ranging from 55 K to greater than 250 K, that react with anti-Ecm29 antibodies. Since the largest brain-specific Ecm29 variant reacts with antibodies to sequences within the N-terminal and C-terminal regions of the protein, but not to the antibody directed to its central region, this putative isoform likely arises by alternative splicing. Some of the smaller Ecm29-positive forms appear to arise by proteolytic processing, but extraction of minced brain fragments in boiling SDS-PAGE sample buffer reveals that all forms are present prior to homogenization. Only the 220-K Ecm29 species is clearly associated with the 26S proteasome; with one exception, the other variants sediment slower than 20S. Direct dissection and immunohistochemistry reveal that these putative Ecm29 isoforms are present throughout the central nervous system. However, anti-Ecm29 immunoreactivity is differentially distributed within subregions of the mouse brain and among cell types, suggesting that Ecm29 isoform distribution contributes to the complexity and regional specificity of brain function." @default.
- W2057183661 created "2016-06-24" @default.
- W2057183661 creator A5018072003 @default.
- W2057183661 creator A5061109878 @default.
- W2057183661 creator A5077603452 @default.
- W2057183661 creator A5079968271 @default.
- W2057183661 creator A5089170848 @default.
- W2057183661 date "2006-09-01" @default.
- W2057183661 modified "2023-09-26" @default.
- W2057183661 title "Multiple Forms of the 26S Proteasome-Associated Protein Ecm29 in the Mouse Brain" @default.
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