FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057183734> ?p ?o ?g. }

• W2057183734 endingPage "481" @default.
• W2057183734 startingPage "447" @default.
• W2057183734 abstract "We have derived a model for the three-dimensional folding of Escherichia coli 16 S ribosomal RNA, using interactive computer graphic methods. It is based on (1) the secondary structure derived from comparative sequence analysis, (2) the three-dimensional co-ordinates for the centers of mass of the 30 S subunit proteins, and (3) the locations of sites in 16 S rRNA that interact with specific ribosomal proteins, from footprinting and crosslinking studies. We present a detailed description of the derivation of the model. About 75% of the RNA chain is sufficiently constrained to provide a useful model. This contains most of the universally conserved core of the molecule. In all but a few instances, protected and crosslinked sites can be placed within or very close to their cognate proteins, while obeying stereochemical rules. The overall shape of the model and locations of specific regions of the RNA correspond well to data derived from electron micrographs of 30 S subunits, although such data were not used to construct the model. Phylogenetic variations in the structure are readily accommodated; as an example, we have modeled the 950-nucleotide mammalian mitochondrial 12 S rRNA by superimposing it on the E. coli structure. The three major RNA domains, as defined by secondary structure, appear to exist as autonomous structural units in three dimensions, for the most part. There is an extensive interface between the 5' and central domains, whereas the 3' major domain has relatively little apparent contact with the rest of the structure. The 5', central and 3' major domains form structures that resemble the body, platform and head, respectively, seen in electron micrographs of 30 S subunits. We discuss possible roles for the ribosomal proteins in stabilizing specific structural features of the RNA during ribosome assembly. The decoding site, as deduced from footprinting and crosslinking studies involving the tRNA anticodon stem-loop, is well-localized. Bases protected from chemical probing by the anticodon stem-loop line the cleft of the subunit. The conserved loop at position 530, which contains some of the bases protected by A site-bound tRNA, is remote (approx. 80 A) from the decoding site. Protection of these bases by the anticodon stem-loop is thus unlikely to be due to direct contact." @default.
• W2057183734 created "2016-06-24" @default.
• W2057183734 creator A5074732561 @default.
• W2057183734 creator A5083929548 @default.
• W2057183734 creator A5089776171 @default.
• W2057183734 date "1988-11-01" @default.
• W2057183734 modified "2023-09-23" @default.
• W2057183734 title "Model for the three-dimensional folding of 16 S ribosomal RNA" @default.
• W2057183734 cites W1480869377 @default.
• W2057183734 cites W1492288245 @default.
• W2057183734 cites W1504940558 @default.
• W2057183734 cites W1507773757 @default.
• W2057183734 cites W1522104342 @default.
• W2057183734 cites W1575379899 @default.
• W2057183734 cites W1597786818 @default.
• W2057183734 cites W1598383366 @default.
• W2057183734 cites W1964292956 @default.
• W2057183734 cites W1967977918 @default.
• W2057183734 cites W1971876128 @default.
• W2057183734 cites W197559234 @default.
• W2057183734 cites W1975671147 @default.
• W2057183734 cites W1980272310 @default.
• W2057183734 cites W1986689971 @default.
• W2057183734 cites W1990084825 @default.
• W2057183734 cites W1990246459 @default.
• W2057183734 cites W1990285498 @default.
• W2057183734 cites W1992326245 @default.
• W2057183734 cites W1993667465 @default.
• W2057183734 cites W1996068101 @default.
• W2057183734 cites W1997763889 @default.
• W2057183734 cites W2001916877 @default.
• W2057183734 cites W2004087135 @default.
• W2057183734 cites W2005783969 @default.
• W2057183734 cites W2011078969 @default.
• W2057183734 cites W2012253277 @default.
• W2057183734 cites W2012795877 @default.
• W2057183734 cites W2017528988 @default.
• W2057183734 cites W2018429609 @default.
• W2057183734 cites W2018559377 @default.
• W2057183734 cites W2026358434 @default.
• W2057183734 cites W2033047771 @default.
• W2057183734 cites W2038261242 @default.
• W2057183734 cites W2039777995 @default.
• W2057183734 cites W2043331698 @default.
• W2057183734 cites W2044893200 @default.
• W2057183734 cites W2045434091 @default.
• W2057183734 cites W2047720257 @default.
• W2057183734 cites W2051995029 @default.
• W2057183734 cites W2059491779 @default.
• W2057183734 cites W2062291239 @default.
• W2057183734 cites W2063798430 @default.
• W2057183734 cites W2066965142 @default.
• W2057183734 cites W2071010415 @default.
• W2057183734 cites W2071735088 @default.
• W2057183734 cites W2072779561 @default.
• W2057183734 cites W2073298150 @default.
• W2057183734 cites W2079014695 @default.
• W2057183734 cites W2082699691 @default.
• W2057183734 cites W2085311805 @default.
• W2057183734 cites W2099187812 @default.
• W2057183734 cites W2121234754 @default.
• W2057183734 cites W2129210977 @default.
• W2057183734 cites W2144970210 @default.
• W2057183734 cites W2150139098 @default.
• W2057183734 cites W2157010941 @default.
• W2057183734 cites W2158533856 @default.
• W2057183734 cites W296378309 @default.
• W2057183734 cites W4230118546 @default.
• W2057183734 cites W4244369451 @default.
• W2057183734 doi "https://doi.org/10.1016/0022-2836(88)90588-8" @default.
• W2057183734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2464693" @default.
• W2057183734 hasPublicationYear "1988" @default.
• W2057183734 type Work @default.
• W2057183734 sameAs 2057183734 @default.
• W2057183734 citedByCount "298" @default.
• W2057183734 countsByYear W20571837342013 @default.
• W2057183734 countsByYear W20571837342014 @default.
• W2057183734 countsByYear W20571837342015 @default.
• W2057183734 countsByYear W20571837342017 @default.
• W2057183734 countsByYear W20571837342018 @default.
• W2057183734 countsByYear W20571837342020 @default.
• W2057183734 crossrefType "journal-article" @default.
• W2057183734 hasAuthorship W2057183734A5074732561 @default.
• W2057183734 hasAuthorship W2057183734A5083929548 @default.
• W2057183734 hasAuthorship W2057183734A5089776171 @default.
• W2057183734 hasConcept C104317684 @default.
• W2057183734 hasConcept C119599485 @default.
• W2057183734 hasConcept C1248232 @default.
• W2057183734 hasConcept C127413603 @default.
• W2057183734 hasConcept C185592680 @default.
• W2057183734 hasConcept C2776545253 @default.
• W2057183734 hasConcept C2778021871 @default.
• W2057183734 hasConcept C2778112365 @default.
• W2057183734 hasConcept C3017666073 @default.
• W2057183734 hasConcept C38062823 @default.
• W2057183734 hasConcept C52721335 @default.
• W2057183734 hasConcept C54355233 @default.
• W2057183734 hasConcept C55493867 @default.

• next