FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057185057> ?p ?o ?g. }

• W2057185057 endingPage "10" @default.
• W2057185057 startingPage "1" @default.
• W2057185057 abstract "<i>Background:</i> Stress influences immune function through mechanisms including an impact on regulatory elements. We have previously demonstrated that glucocorticoids (GCs) and catecholamines can influence immunomodulation including changes in Th1/Th2 cytokine production. These immunoregulatory imbalances are associated with elevated cortisol in vivo and in the presence of GCs in vitro. <i>Methods:</i> We examined the effects of dexamethasone (DEX) and epinephrine (EPI) on the balance of regulatory T cells (Tregs), Th1/Th2 cytokine gene expression by peripheral blood mononuclear cells (PBMCs) from 16 normal subjects after 24-hour and 11-day cultures with tetanus toxoid. We wished to determine whether the immunomodulatory effects of stress hormones involved differences in costimulatory signal pathways including CD28, CTLA-4 (CD152), and CD80/86. <i>Results:</i> Our results revealed that FoxP3 mRNA expression (representing Tregs) was decreased in PBMCs cultured with DEX relative to the control within 24 h (short term). DEX decreased the Th1/Th2 cytokine mRNA balance after 11 days (long term). CD28 and CD80 mRNA were decreased in short-term incubation with DEX whereas the effect of inhibition by DEX on CTLA-4 mRNA was detected only in long-term cultures. <i>Conclusions:</i> These results suggest that the Treg (FoxP3 mRNA) and CD28/CD80 costimulatory signal pathway may be a target of stress hormones in acute stress while the CTLA-4/CD80–86 pathway may be more susceptible in chronic stress." @default.
• W2057185057 created "2016-06-24" @default.
• W2057185057 creator A5039468195 @default.
• W2057185057 creator A5077027296 @default.
• W2057185057 date "2010-07-07" @default.
• W2057185057 modified "2023-09-25" @default.
• W2057185057 title "Immunomodulatory Effects of in vitroStress Hormones on FoxP3, Th1/Th2 Cytokine and Costimulatory Molecule mRNA Expression in Human Peripheral Blood Mononuclear Cells" @default.
• W2057185057 cites W1489480103 @default.
• W2057185057 cites W1577577364 @default.
• W2057185057 cites W1606242255 @default.
• W2057185057 cites W1837305140 @default.
• W2057185057 cites W1968819665 @default.
• W2057185057 cites W1969418564 @default.
• W2057185057 cites W1977557166 @default.
• W2057185057 cites W1977818265 @default.
• W2057185057 cites W1978903184 @default.
• W2057185057 cites W1979001814 @default.
• W2057185057 cites W1991600170 @default.
• W2057185057 cites W1994969460 @default.
• W2057185057 cites W1995335058 @default.
• W2057185057 cites W2000138932 @default.
• W2057185057 cites W2011368430 @default.
• W2057185057 cites W2015644712 @default.
• W2057185057 cites W2017195704 @default.
• W2057185057 cites W2025704460 @default.
• W2057185057 cites W2030597357 @default.
• W2057185057 cites W2031352461 @default.
• W2057185057 cites W2036383793 @default.
• W2057185057 cites W2038548099 @default.
• W2057185057 cites W2039423387 @default.
• W2057185057 cites W2063391264 @default.
• W2057185057 cites W2069712305 @default.
• W2057185057 cites W2077222278 @default.
• W2057185057 cites W2079231292 @default.
• W2057185057 cites W2085332498 @default.
• W2057185057 cites W2086595653 @default.
• W2057185057 cites W2107759391 @default.
• W2057185057 cites W2112670248 @default.
• W2057185057 cites W2116634463 @default.
• W2057185057 cites W2124873497 @default.
• W2057185057 cites W2128211931 @default.
• W2057185057 cites W2131371843 @default.
• W2057185057 cites W2141347954 @default.
• W2057185057 cites W2167012568 @default.
• W2057185057 cites W2171026458 @default.
• W2057185057 doi "https://doi.org/10.1159/000311450" @default.
• W2057185057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20606488" @default.
• W2057185057 hasPublicationYear "2010" @default.
• W2057185057 type Work @default.
• W2057185057 sameAs 2057185057 @default.
• W2057185057 citedByCount "36" @default.
• W2057185057 countsByYear W20571850572012 @default.
• W2057185057 countsByYear W20571850572013 @default.
• W2057185057 countsByYear W20571850572014 @default.
• W2057185057 countsByYear W20571850572015 @default.
• W2057185057 countsByYear W20571850572016 @default.
• W2057185057 countsByYear W20571850572017 @default.
• W2057185057 countsByYear W20571850572018 @default.
• W2057185057 countsByYear W20571850572019 @default.
• W2057185057 countsByYear W20571850572020 @default.
• W2057185057 countsByYear W20571850572021 @default.
• W2057185057 countsByYear W20571850572022 @default.
• W2057185057 crossrefType "journal-article" @default.
• W2057185057 hasAuthorship W2057185057A5039468195 @default.
• W2057185057 hasAuthorship W2057185057A5077027296 @default.
• W2057185057 hasConcept C126322002 @default.
• W2057185057 hasConcept C134018914 @default.
• W2057185057 hasConcept C137061746 @default.
• W2057185057 hasConcept C148125776 @default.
• W2057185057 hasConcept C154317977 @default.
• W2057185057 hasConcept C202751555 @default.
• W2057185057 hasConcept C203014093 @default.
• W2057185057 hasConcept C2776090121 @default.
• W2057185057 hasConcept C2778297628 @default.
• W2057185057 hasConcept C2778690821 @default.
• W2057185057 hasConcept C2779727006 @default.
• W2057185057 hasConcept C39347974 @default.
• W2057185057 hasConcept C55493867 @default.
• W2057185057 hasConcept C71315377 @default.
• W2057185057 hasConcept C71924100 @default.
• W2057185057 hasConcept C86803240 @default.
• W2057185057 hasConcept C8891405 @default.
• W2057185057 hasConceptScore W2057185057C126322002 @default.
• W2057185057 hasConceptScore W2057185057C134018914 @default.
• W2057185057 hasConceptScore W2057185057C137061746 @default.
• W2057185057 hasConceptScore W2057185057C148125776 @default.
• W2057185057 hasConceptScore W2057185057C154317977 @default.
• W2057185057 hasConceptScore W2057185057C202751555 @default.
• W2057185057 hasConceptScore W2057185057C203014093 @default.
• W2057185057 hasConceptScore W2057185057C2776090121 @default.
• W2057185057 hasConceptScore W2057185057C2778297628 @default.
• W2057185057 hasConceptScore W2057185057C2778690821 @default.
• W2057185057 hasConceptScore W2057185057C2779727006 @default.
• W2057185057 hasConceptScore W2057185057C39347974 @default.
• W2057185057 hasConceptScore W2057185057C55493867 @default.
• W2057185057 hasConceptScore W2057185057C71315377 @default.
• W2057185057 hasConceptScore W2057185057C71924100 @default.
• W2057185057 hasConceptScore W2057185057C86803240 @default.

• next