Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057185413> ?p ?o ?g. }
- W2057185413 endingPage "869" @default.
- W2057185413 startingPage "859" @default.
- W2057185413 abstract "Abstract In this paper, we report the discovery and the synthesis of novel, potential antipsychotic piperidine‐2,6‐dione derivatives combining potent dopamine D 2 , D 3 and serotonin 5‐HT 1A , 5‐HT 2A , 5‐HT 2C receptor properties. We describe the structure–activity relationships that led us to the promising derivative: 1‐(4‐(4‐(6‐fluorobenzo[d]isoxazol‐3‐yl)piperidin‐1‐yl)butyl)‐4‐(4‐chlorophenyl)‐piperidine‐2,6‐dione 5 . The unique pharmacological features of compound 5 are a high affinity for dopamine D 2 , D 3 and serotonin 5‐HT 1A , 5‐HT 2A , 5‐HT 2C receptors, together with a low affinity for the H 1 receptor (to reduce the risk of obesity under chronic treatment). In a behavioral model predictive of positive symptoms, compound 5 inhibited apomorphine‐induced climbing behavior and MK‐801‐induced hyperactivity with no extrapyramidal symptoms liability in mice. In particular, compound 5 was more potent than clozapine." @default.
- W2057185413 created "2016-06-24" @default.
- W2057185413 creator A5021687717 @default.
- W2057185413 creator A5040113983 @default.
- W2057185413 creator A5044121496 @default.
- W2057185413 creator A5046017564 @default.
- W2057185413 creator A5079317155 @default.
- W2057185413 date "2012-08-08" @default.
- W2057185413 modified "2023-10-18" @default.
- W2057185413 title "Synthesis and Evaluation of a Series of Piperidine-2,6-dione-piperazine (piperidine) Derivatives as Multireceptor Atypical Antipsychotics" @default.
- W2057185413 cites W119245859 @default.
- W2057185413 cites W1895992443 @default.
- W2057185413 cites W1966772380 @default.
- W2057185413 cites W1967367855 @default.
- W2057185413 cites W1976049732 @default.
- W2057185413 cites W1981821582 @default.
- W2057185413 cites W1982101530 @default.
- W2057185413 cites W1982363548 @default.
- W2057185413 cites W1995638515 @default.
- W2057185413 cites W1995716681 @default.
- W2057185413 cites W1996187192 @default.
- W2057185413 cites W2000375438 @default.
- W2057185413 cites W2009442121 @default.
- W2057185413 cites W2022926817 @default.
- W2057185413 cites W2023567327 @default.
- W2057185413 cites W2037022348 @default.
- W2057185413 cites W2046315930 @default.
- W2057185413 cites W2055366180 @default.
- W2057185413 cites W2064337319 @default.
- W2057185413 cites W2070357412 @default.
- W2057185413 cites W2073965152 @default.
- W2057185413 cites W2075027890 @default.
- W2057185413 cites W2077604455 @default.
- W2057185413 cites W2084253999 @default.
- W2057185413 cites W2093531044 @default.
- W2057185413 cites W2094259516 @default.
- W2057185413 cites W2095213614 @default.
- W2057185413 cites W2097062805 @default.
- W2057185413 cites W2102191077 @default.
- W2057185413 cites W2108988641 @default.
- W2057185413 cites W2117669265 @default.
- W2057185413 cites W2127339766 @default.
- W2057185413 cites W2132551489 @default.
- W2057185413 cites W2159674293 @default.
- W2057185413 cites W2161026345 @default.
- W2057185413 cites W2951501929 @default.
- W2057185413 cites W46711357 @default.
- W2057185413 doi "https://doi.org/10.1002/ardp.201200023" @default.
- W2057185413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22886598" @default.
- W2057185413 hasPublicationYear "2012" @default.
- W2057185413 type Work @default.
- W2057185413 sameAs 2057185413 @default.
- W2057185413 citedByCount "12" @default.
- W2057185413 countsByYear W20571854132013 @default.
- W2057185413 countsByYear W20571854132014 @default.
- W2057185413 countsByYear W20571854132015 @default.
- W2057185413 countsByYear W20571854132016 @default.
- W2057185413 countsByYear W20571854132019 @default.
- W2057185413 countsByYear W20571854132020 @default.
- W2057185413 countsByYear W20571854132022 @default.
- W2057185413 countsByYear W20571854132023 @default.
- W2057185413 crossrefType "journal-article" @default.
- W2057185413 hasAuthorship W2057185413A5021687717 @default.
- W2057185413 hasAuthorship W2057185413A5040113983 @default.
- W2057185413 hasAuthorship W2057185413A5044121496 @default.
- W2057185413 hasAuthorship W2057185413A5046017564 @default.
- W2057185413 hasAuthorship W2057185413A5079317155 @default.
- W2057185413 hasConcept C118552586 @default.
- W2057185413 hasConcept C126322002 @default.
- W2057185413 hasConcept C170493617 @default.
- W2057185413 hasConcept C185592680 @default.
- W2057185413 hasConcept C2775864247 @default.
- W2057185413 hasConcept C2776201271 @default.
- W2057185413 hasConcept C2776412080 @default.
- W2057185413 hasConcept C2777525119 @default.
- W2057185413 hasConcept C2778938600 @default.
- W2057185413 hasConcept C2780864610 @default.
- W2057185413 hasConcept C2781462491 @default.
- W2057185413 hasConcept C513476851 @default.
- W2057185413 hasConcept C53910766 @default.
- W2057185413 hasConcept C55493867 @default.
- W2057185413 hasConcept C71240020 @default.
- W2057185413 hasConcept C71924100 @default.
- W2057185413 hasConcept C98274493 @default.
- W2057185413 hasConceptScore W2057185413C118552586 @default.
- W2057185413 hasConceptScore W2057185413C126322002 @default.
- W2057185413 hasConceptScore W2057185413C170493617 @default.
- W2057185413 hasConceptScore W2057185413C185592680 @default.
- W2057185413 hasConceptScore W2057185413C2775864247 @default.
- W2057185413 hasConceptScore W2057185413C2776201271 @default.
- W2057185413 hasConceptScore W2057185413C2776412080 @default.
- W2057185413 hasConceptScore W2057185413C2777525119 @default.
- W2057185413 hasConceptScore W2057185413C2778938600 @default.
- W2057185413 hasConceptScore W2057185413C2780864610 @default.
- W2057185413 hasConceptScore W2057185413C2781462491 @default.
- W2057185413 hasConceptScore W2057185413C513476851 @default.
- W2057185413 hasConceptScore W2057185413C53910766 @default.
- W2057185413 hasConceptScore W2057185413C55493867 @default.