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- W2057185879 abstract "Carbapenemase (KPC)-producing Klebsiella pneumoniae have been disseminating worldwide during the last decade, and currently, are recognized as the leading causes of severe nosocomial infections mainly in intensive care unit (ICU) patients. 1 Widespread hospital outbreaks due to KPC-producing K. pneumoniae (KPC-Kp) have been reported in the United States, Israel, and Greece. 2–4 The blaKPC genes encoding KPC enzymes reside on transferable plasmids and are often linked with other resistance determinants conferring resistance not only to carbapenems but also to all beta-lactam antibiotics, including beta-lactam/beta-lactamase inhibitor combinations, extended-spectrum cephalosporins, monobactams, and also to fluoroquinolones and some aminoglycosides. 5 Antibiotic treatment options for the management of the infections caused by these multidrug-resistant Enterobacteriaceae are often limited to colistin (COL), tigecycline (TIG), gentamicin (GM), amikacin, fosfomycin (FOS), and polymyxin B. 6 However, these agents when used as monotherapy in critically ill patients with severe infections due to KPCKp resulted in clinical failures with high mortality rates. 7 In contrast, combination antibiotic regimens have been proven more effective and are associated with improved survival rates in patients with bloodstream infections. 8,9 In this study, we investigated the in vitro activities of imipenem (IMI), meropenem (MER), doripenem (DORI), COL, TIG, FOS, rifampicin (RIF), and GM alone and in combination, against COL-resistant (CST-R) KPC-Kp isolated in our institution. The strains tested comprised 30 non-duplicate" @default.
- W2057185879 created "2016-06-24" @default.
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- W2057185879 date "2014-09-23" @default.
- W2057185879 modified "2023-09-23" @default.
- W2057185879 title "Evaluation of antimicrobial combinations against colistin-resistant carbapenemase (KPC)-producingKlebsiella pneumoniae" @default.
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- W2057185879 doi "https://doi.org/10.1179/1973947814y.0000000218" @default.
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