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• W2057188822 endingPage "100" @default.
• W2057188822 startingPage "88" @default.
• W2057188822 abstract "Classical biological methods involving analyses of one or several genes have been the mainstay for studying the pathogenesis of neurodegenerative disorders. However, it has become clear that these diseases exhibit complex molecular interactions involving both host genomes and environmental determinants. Systems biology represents an integrated and deeper investigation of interacting biomolecules within cells or organisms. This approach has only recently become feasible as high-throughput technologies including cDNA microarrays, mass spectrometric analyses of proteins and lipids together with rigorous bioinformatics have evolved. Herein, we review recent developments from studies of systems biology applied to multiple sclerosis, Alzheimer's disease and HIV-associated dementia as three prototypic neurodegenerative disorders. Existing high-content data derived from clinically and experimentally derived neural tissues point to convergent pathways among these neurodegenerative disorders, which transcend descriptive studies to reach a more integrated understanding of disease pathogenesis and, in some instances, highlighting 'druggable' network nodes." @default.
• W2057188822 created "2016-06-24" @default.
• W2057188822 creator A5053252393 @default.
• W2057188822 creator A5085017229 @default.
• W2057188822 creator A5090853761 @default.
• W2057188822 date "2009-02-01" @default.
• W2057188822 modified "2023-09-24" @default.
• W2057188822 title "Deciphering complex mechanisms in neurodegenerative diseases: the advent of systems biology" @default.
• W2057188822 cites W1510147084 @default.
• W2057188822 cites W1515965683 @default.
• W2057188822 cites W15770206 @default.
• W2057188822 cites W1584846756 @default.
• W2057188822 cites W1607863238 @default.
• W2057188822 cites W1907661964 @default.
• W2057188822 cites W1964174134 @default.
• W2057188822 cites W1965942536 @default.
• W2057188822 cites W1969352987 @default.
• W2057188822 cites W1971916732 @default.
• W2057188822 cites W1974244813 @default.
• W2057188822 cites W1975783279 @default.
• W2057188822 cites W1977277944 @default.
• W2057188822 cites W1977813572 @default.
• W2057188822 cites W1977877423 @default.
• W2057188822 cites W1978486653 @default.
• W2057188822 cites W1979633031 @default.
• W2057188822 cites W1980543900 @default.
• W2057188822 cites W1987206979 @default.
• W2057188822 cites W1989957637 @default.
• W2057188822 cites W1992594876 @default.
• W2057188822 cites W1994803330 @default.
• W2057188822 cites W1996838219 @default.
• W2057188822 cites W1997311500 @default.
• W2057188822 cites W1997598984 @default.
• W2057188822 cites W2006782547 @default.
• W2057188822 cites W2007360114 @default.
• W2057188822 cites W2008352401 @default.
• W2057188822 cites W2009969882 @default.
• W2057188822 cites W2011633018 @default.
• W2057188822 cites W2018342879 @default.
• W2057188822 cites W2019926860 @default.
• W2057188822 cites W2019997223 @default.
• W2057188822 cites W2020876610 @default.
• W2057188822 cites W2023922415 @default.
• W2057188822 cites W2024289001 @default.
• W2057188822 cites W2026539615 @default.
• W2057188822 cites W2026924553 @default.
• W2057188822 cites W2030104330 @default.
• W2057188822 cites W2031007823 @default.
• W2057188822 cites W2037708171 @default.
• W2057188822 cites W2040949523 @default.
• W2057188822 cites W2041042514 @default.
• W2057188822 cites W2041080239 @default.
• W2057188822 cites W2041504972 @default.
• W2057188822 cites W2043281805 @default.
• W2057188822 cites W2045497115 @default.
• W2057188822 cites W2047579358 @default.
• W2057188822 cites W2050706870 @default.
• W2057188822 cites W2051179156 @default.
• W2057188822 cites W2052840246 @default.
• W2057188822 cites W2054588014 @default.
• W2057188822 cites W2060393046 @default.
• W2057188822 cites W2061378782 @default.
• W2057188822 cites W2069201165 @default.
• W2057188822 cites W2069508712 @default.
• W2057188822 cites W2076206556 @default.
• W2057188822 cites W2078891878 @default.
• W2057188822 cites W2080274663 @default.
• W2057188822 cites W2081352868 @default.
• W2057188822 cites W2083358433 @default.
• W2057188822 cites W2084693759 @default.
• W2057188822 cites W2085862068 @default.
• W2057188822 cites W2087423729 @default.
• W2057188822 cites W2088997949 @default.
• W2057188822 cites W2090348783 @default.
• W2057188822 cites W2092134500 @default.
• W2057188822 cites W2096483316 @default.
• W2057188822 cites W2097463865 @default.
• W2057188822 cites W2101152074 @default.
• W2057188822 cites W2106736210 @default.
• W2057188822 cites W2112043533 @default.
• W2057188822 cites W2113291839 @default.
• W2057188822 cites W2114729479 @default.
• W2057188822 cites W2115097567 @default.
• W2057188822 cites W2121806371 @default.
• W2057188822 cites W2121916657 @default.
• W2057188822 cites W2123584222 @default.
• W2057188822 cites W2124777889 @default.
• W2057188822 cites W2130983270 @default.
• W2057188822 cites W2134334295 @default.
• W2057188822 cites W2135608710 @default.
• W2057188822 cites W2136059495 @default.
• W2057188822 cites W2137052537 @default.
• W2057188822 cites W2137263943 @default.
• W2057188822 cites W2137646553 @default.
• W2057188822 cites W2144239158 @default.
• W2057188822 cites W2151716994 @default.
• W2057188822 cites W2154022519 @default.
• W2057188822 cites W2156246479 @default.

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