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- W2057192907 abstract "Nitric oxide (NO) plays an important role in physiological functions in the body, naturally synthesized by nitric oxide synthase. NO has been shown to enhance wound healing, generating research interest in the incorporation of NO into thromboresistant polymers for medical devices. Such polymers can be processed by melt-spinning to create surgical suture type materials. These melt-spun sutures can have the high tensile strength and durability necessary for wound closure. NO release from the suture can be controlled by application of a biodegradable coating. In this work, an acrylonitrile-co-1-vinylimidazole (AN/VIM) copolymer was melt-spun and coated with PCL. The coated suture fibers were studied for NO storage and release. Addition of a PCL coating significantly slows release of the NO compared to the uncoated AN/VIM suture. Over 24 h, the coated suture released 46 (±12) µmol NO/g AN." @default.
- W2057192907 created "2016-06-24" @default.
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- W2057192907 date "2014-06-01" @default.
- W2057192907 modified "2023-09-24" @default.
- W2057192907 title "Coated melt-spun acrylonitrile-based suture for delayed release of nitric oxide" @default.
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- W2057192907 doi "https://doi.org/10.1016/j.matlet.2014.03.174" @default.
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