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• W2057195811 abstract "In rats, a critical period exists around postnatal day (P) 12-13, when an imbalance between heightened inhibition and suppressed excitation led to a weakened ventilatory and metabolic response to acute hypoxia. An open question was whether the two genders follow the same or different developmental trends throughout the first 3 postnatal weeks and whether the critical period exists in one or both genders. The present large-scale, in-depth ventilatory and metabolic study was undertaken to address this question. Our data indicated that: (1) the ventilatory and metabolic rates in both normoxia and acute hypoxia were comparable between the two genders from P0 to P21; thus, gender was never significant as a main effect; and (2) the age effect was highly significant in all parameters studies for both genders, and both genders exhibited a significantly weakened response to acute hypoxia during the critical period. Thus, the two genders have comparable developmental trends, and the critical period exists in both genders in rats." @default.
• W2057195811 created "2016-06-24" @default.
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• W2057195811 date "2013-08-01" @default.
• W2057195811 modified "2023-09-26" @default.
• W2057195811 title "Gender considerations in ventilatory and metabolic development in rats: Special emphasis on the critical period" @default.
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• W2057195811 doi "https://doi.org/10.1016/j.resp.2013.06.013" @default.
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