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• W2057200052 abstract "The effects of morphine, naloxone, and diallylnormorphine were examined on the continuous, electric-shock postponement behaviour of the squirrel monkey. Under this schedule, a lever-pressing response postponed the delivery of brief electric shocks delivered to the monkey's tail. Dose–response curves were determined for morphine (0.3–10 mg/kg, im) and naloxone (0.1–10 mg/kg, im), separately. Naloxone (0.1–3 mg/kg, im) and diallylnormorphine (0.1–3 mg/kg, im) antagonized the acute rate-suppressive effect of morphine given at a dose of 10 mg/kg. Naloxone was found to be approximately 10 times more potent than diallylnormorphine in reversing the acute suppression of responding induced by morphine. In subsequent experiments, monkeys received morphine (10 mg/kg, im) on a daily basis, each injection being given 5 min prior to behavioural testing. The rate-suppressive effect of morphine diminished over a series of 10 consecutive sessions, indicating the development of tolerance to this effect of morphine. Naloxone (0.1–3 mg/kg, im), given in conjunction with morphine, in morphine-tolerant monkeys produced dose-dependent increases in responding that greatly exceeded overall rates seen during reversal of the acute effects of morphine or naloxone tested prior to the induction of tolerance at identical doses. These monkeys become extremely agitated, vomiting was often seen, and contorted postures were evident; despite signs of antagonist-precipitated abstinence, response rates usually exceeded 1/s when naloxone was given in conjunction with morphine (10 mg/kg, im) at doses of 1 or 3 mg/kg, im. These results illustrate the sensitivity of operant responding maintained by a schedule of electric-shock postponement to assess the development of morphine tolerance accompanied by low-grade physiological dependence in the squirrel monkey." @default.
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• W2057200052 title "Effects of morphine, naloxone, and diallylnormorphine upon behaviour maintained by electric-shock postponement in squirrel monkeys" @default.
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• W2057200052 doi "https://doi.org/10.1139/y79-014" @default.
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