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- W2057201600 abstract "Abstract Vitamin D and its metabolites do not circulate free but are bound to specific plasma transport proteins that solubilize them and protect them from oxidative inactivation. A specific vitamin D transport protein has been demonstrated in man, rat and chick; it preferentially binds 25-hydroxyvitamin D (25-(OH)D), the major active form of the vitamin in the circulation. The binding of vitamin D and its analogs by the D/25-(OH)D transport protein from rat plasma involves recognition of structural properties and steric configuration of both the single ring and the side chain. The C-25 hydroxyl group plus the vitamin D 3 configuration of both the side chain and the single ring maximize the binding. Although the binding of vitamin D 2 and its analogs by human and rat D/25-(OH)D transport protein is roughly equivalent to that of vitamin D 3 and its analogs, abnormal plasma binding of vitamin D 2 and 25-(OH)D 2 by the D/25-(OH)D transport protein in chick plasma may play an important role in the increased metabolic inactivation of these compounds and the resultant decreased antirachitic potency of vitamin D 2 in the chick. Preliminary studies suggest that 1,25-(OH) 2 D is carried by the D/25-(OH)D transport protein in rat plasma but that a specific dihydroxy transport protein also exists in human plasma. These studies suggest that transport proteins play an important role in the facilitation of vitamin D transport and normal vitamin D metabolism." @default.
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- W2057201600 date "1974-07-01" @default.
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- W2057201600 title "The physiologic significance of plasma transport of vitamin D and metabolites" @default.
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- W2057201600 doi "https://doi.org/10.1016/0002-9343(74)90767-0" @default.
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