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- W2057201670 abstract "Abstract Intramuscular administrations of a saline suspension of 17- α -methyl-17- β -hydroxyandrosta-Δ 1, 4 -3-one (methandrostenolone) ranging from 0.25 to 10 mg per kilogram body weight per day were given to noncastrated White Rock cockerels from the fifth to the seventh week of age. It was found that the anabolic response to this steroid in chicks was similar to that of other androgens. Excessive dosages (1.25 mg per kilogram per day) resulted in slower gains in body weight, while moderate dosages (0.50 mg per kilogram per day) produced small but significant increases in weight over saline-injected controls. Although not as clearly defined, a similar pattern was observed in retention of nitrogen. Pectoralis muscle weights were depressed with 2.50 mg per kilogram per day while 5.00 mg per kilogram per day was required to reduce semi-membranosus weights. In general these reductions in muscle mass by excessive administration of the steroid could be accounted for by the lower body weights; however, the reductions in pectoralis weight at the 10 mg per kilogram per day dose level were greater than could be accounted for by correction for the lower body weight. Concentration of nitrogen in muscle or the percentage of water were not significantly changed at the dosages employed. Levels of the hormone sufficient to induce significant gains in weight and nitrogen retention also caused noticeable changes in sexual characteristics, including increased comb weight and maturation of the germinal epithelium within the seminiferous tubules." @default.
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- W2057201670 date "1964-04-01" @default.
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- W2057201670 title "Nitrogen metabolism in cockerels treated with 17-α-methyl-17-β-hydroxyandrosta-Δ1, 4-3-one (methandrostenolone)" @default.
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- W2057201670 doi "https://doi.org/10.1016/0016-6480(64)90046-2" @default.
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