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• W2057208081 endingPage "132" @default.
• W2057208081 startingPage "125" @default.
• W2057208081 abstract "Anergy, or T cell unresponsiveness to antigen, is one mechanism of T cell tolerance. However, the signaling events that lead to immune tolerance are not well understood. A common assumption is that soluble antigens, such as food antigens, are poor immunogens and induce tolerance because they fail to upregulate co-stimulatory molecules on the professional APC. Engagement of CD40 through a stimulatory antibody causes the upregulation of these costimulatory molecules. Using a CD4+ T cell adoptive transfer model specific to ovalbumin (OVA), we show that after upregulation of CD86 on APC through CD40 stimulation in vivo, T cells from OVA-fed mice remain refractory to proliferation, interleukin (IL)-2 and interferon (IFN)-gamma production. We conclude that upregulation of CD86 alone does not inhibit oral tolerance induction of CD4+ T cells, indicating that additional signals are involved in the decision process for CD4+ T cells to commit to tolerance versus sensitization. Our data challenge the belief that reconstitution of a costimulatory signal in the presence of soluble antigen is sufficient to override T cell tolerance and anergy." @default.
• W2057208081 created "2016-06-24" @default.
• W2057208081 creator A5006454832 @default.
• W2057208081 creator A5046764208 @default.
• W2057208081 date "2002-11-01" @default.
• W2057208081 modified "2023-10-10" @default.
• W2057208081 title "CD40 stimulation in vivo does not inhibit CD4+ T cell tolerance to soluble antigens" @default.
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• W2057208081 doi "https://doi.org/10.1016/s0165-2478(02)00153-0" @default.
• W2057208081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12270549" @default.
• W2057208081 hasPublicationYear "2002" @default.
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