FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057210366> ?p ?o ?g. }

• W2057210366 endingPage "15945" @default.
• W2057210366 startingPage "15944" @default.
• W2057210366 abstract "Novel artificial ion channels (1 and 2) based on CB[n] (n = 6 and 5, respectively) synthetic receptors with carbonyl-fringed portals (diameter 3.9 and 2.4 Å, respectively) can transport proton and alkali metal ions across a lipid membrane with ion selectivity. Fluorometric experiments using large unilamellar vesicles showed that 1 mediates proton transport across the membranes, which can be blocked by a neurotransmitter, acetylcholine, reminiscent of the blocking of the K+ channels by polyamines. The alkali metal ion transport activity of 1 follows the order of Li+ > Cs+ ≈ Rb+ > K+ > Na+, which is opposite to the binding affinity of CB[6] toward alkali metal ions. On the other hand, the transport activity of 2 follows the order of Li+ > Na+, which is also opposite to the binding affinity of 2 toward these metal ions, but virtually no transport was observed for K+, Rb+, and Cs+. It is presumably because the carbonyl-fringed portal size of 2 (diameter 2.4 Å) is smaller than the diameters of these alkali metal ions. To determine the transport mechanism, voltage-clamp experiments on planar bilayer lipid membranes were carried out. The experiments showed that a single-channel current of 1 for Cs+ transport is ∼5 pA, which corresponds to an ion flux of ∼3 × 107 ions/s. These results are consistent with an ion channel mechanism. Not only the structural resemblance to the selectivity filter of K+ channels but also the remarkable ion selectivity makes this model system unique." @default.
• W2057210366 created "2016-06-24" @default.
• W2057210366 creator A5006142169 @default.
• W2057210366 creator A5025480171 @default.
• W2057210366 creator A5031635205 @default.
• W2057210366 creator A5040531350 @default.
• W2057210366 creator A5041133038 @default.
• W2057210366 creator A5043869954 @default.
• W2057210366 creator A5046648821 @default.
• W2057210366 creator A5051308805 @default.
• W2057210366 creator A5087981887 @default.
• W2057210366 creator A5090880469 @default.
• W2057210366 date "2004-11-13" @default.
• W2057210366 modified "2023-10-12" @default.
• W2057210366 title "Artificial Ion Channel Formed by Cucurbit[<i>n</i>]uril Derivatives with a Carbonyl Group Fringed Portal Reminiscent of the Selectivity Filter of K⁺Channels" @default.
• W2057210366 cites W1492349014 @default.
• W2057210366 cites W1678350171 @default.
• W2057210366 cites W1867012516 @default.
• W2057210366 cites W1963673259 @default.
• W2057210366 cites W1963674676 @default.
• W2057210366 cites W1972194130 @default.
• W2057210366 cites W1986198239 @default.
• W2057210366 cites W1986510139 @default.
• W2057210366 cites W1988901585 @default.
• W2057210366 cites W1989317862 @default.
• W2057210366 cites W1994214442 @default.
• W2057210366 cites W2011676285 @default.
• W2057210366 cites W2017268899 @default.
• W2057210366 cites W2025458478 @default.
• W2057210366 cites W2025489455 @default.
• W2057210366 cites W2027859380 @default.
• W2057210366 cites W2039702613 @default.
• W2057210366 cites W2042110025 @default.
• W2057210366 cites W2043672286 @default.
• W2057210366 cites W2045247642 @default.
• W2057210366 cites W2063567177 @default.
• W2057210366 cites W2075566899 @default.
• W2057210366 cites W2082566220 @default.
• W2057210366 cites W2091919373 @default.
• W2057210366 cites W2124653618 @default.
• W2057210366 cites W2128922637 @default.
• W2057210366 cites W2143070723 @default.
• W2057210366 cites W2153464333 @default.
• W2057210366 cites W2165628546 @default.
• W2057210366 cites W2809722643 @default.
• W2057210366 cites W2953008624 @default.
• W2057210366 cites W4234426833 @default.
• W2057210366 cites W611995398 @default.
• W2057210366 doi "https://doi.org/10.1021/ja044748j" @default.
• W2057210366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15584711" @default.
• W2057210366 hasPublicationYear "2004" @default.
• W2057210366 type Work @default.
• W2057210366 sameAs 2057210366 @default.
• W2057210366 citedByCount "160" @default.
• W2057210366 countsByYear W20572103662012 @default.
• W2057210366 countsByYear W20572103662013 @default.
• W2057210366 countsByYear W20572103662014 @default.
• W2057210366 countsByYear W20572103662015 @default.
• W2057210366 countsByYear W20572103662016 @default.
• W2057210366 countsByYear W20572103662017 @default.
• W2057210366 countsByYear W20572103662018 @default.
• W2057210366 countsByYear W20572103662019 @default.
• W2057210366 countsByYear W20572103662020 @default.
• W2057210366 countsByYear W20572103662021 @default.
• W2057210366 countsByYear W20572103662022 @default.
• W2057210366 countsByYear W20572103662023 @default.
• W2057210366 crossrefType "journal-article" @default.
• W2057210366 hasAuthorship W2057210366A5006142169 @default.
• W2057210366 hasAuthorship W2057210366A5025480171 @default.
• W2057210366 hasAuthorship W2057210366A5031635205 @default.
• W2057210366 hasAuthorship W2057210366A5040531350 @default.
• W2057210366 hasAuthorship W2057210366A5041133038 @default.
• W2057210366 hasAuthorship W2057210366A5043869954 @default.
• W2057210366 hasAuthorship W2057210366A5046648821 @default.
• W2057210366 hasAuthorship W2057210366A5051308805 @default.
• W2057210366 hasAuthorship W2057210366A5087981887 @default.
• W2057210366 hasAuthorship W2057210366A5090880469 @default.
• W2057210366 hasConcept C118792377 @default.
• W2057210366 hasConcept C130316041 @default.
• W2057210366 hasConcept C145148216 @default.
• W2057210366 hasConcept C161790260 @default.
• W2057210366 hasConcept C170493617 @default.
• W2057210366 hasConcept C178790620 @default.
• W2057210366 hasConcept C179104552 @default.
• W2057210366 hasConcept C185592680 @default.
• W2057210366 hasConcept C198091228 @default.
• W2057210366 hasConcept C39944091 @default.
• W2057210366 hasConcept C41625074 @default.
• W2057210366 hasConcept C50254741 @default.
• W2057210366 hasConcept C544153396 @default.
• W2057210366 hasConcept C55493867 @default.
• W2057210366 hasConcept C99975950 @default.
• W2057210366 hasConceptScore W2057210366C118792377 @default.
• W2057210366 hasConceptScore W2057210366C130316041 @default.
• W2057210366 hasConceptScore W2057210366C145148216 @default.
• W2057210366 hasConceptScore W2057210366C161790260 @default.
• W2057210366 hasConceptScore W2057210366C170493617 @default.
• W2057210366 hasConceptScore W2057210366C178790620 @default.

• next