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• W2057216398 endingPage "82" @default.
• W2057216398 startingPage "1" @default.
• W2057216398 abstract "El kindling es un modelo que consiste en la repetición de estímulos para producir crisis epilépticas espontáneas (CEE).Distinguir efecto convulsivo y subconvulsivo en ratones viejos y jóvenes, para evaluar las diferencias entre la ictogénesis y epileptogénesis.Se realizó kindling rápido utilizando pentilentetrazol (PTZ) en ratones C57BL/6. Utilizando dosis convulsivas (C) (75 mg/kg en una inyección) y subconvulsiva (SC) (10 mg/kg cada cinco minutos por 30 minutos, siendo un total de cinco inyecciones). Se conformaron cuatro grupos, sujetos de experimentación (SE) jóvenes (<32 semanas; C = 8; SC = 9) y 16 SE viejos (>32 semanas; C = 8; SC = 8). Utilizando Score de Racine (SR). Estadística descriptiva.Realizamos 16 protocolos C y 17 protocolos SC. El tiempo de latencia a fase 1 en segundo es menor en C viejos (50,5 seg) que en C jóvenes (170,3). En SC, fue mayor en el grupo de viejos 170,3 vs. jóvenes 105,5 (p = 0,001). El grupo C jóvenes presentaron mayor tiempo durante fase 1 a 3, y C viejos durante fase 4 y 5. Los SC jóvenes presentan mayor duración en fase 2, a diferencia de SC viejos con duración lineal en diferentes fases SR (p = 0,001). No hubo diferencias en muerte espontánea.El tiempo de latencia a fase 1 fue menor en SE viejos convulsivos y mayor que los SE jóvenes SC, sugiriendo mayor ictogénesis y menos epileptogénesis en la población vieja. La tendencia en SE viejos a permanecer más tiempo en fases 4 y 5 en dosis convulsivas sugiere mayor tendencia a ictogénesis y mayor severidad de las CE.Kindling Model consist sequential injections of a dose Pentylenetetrazole causing spontaneous seizures. (ES)Compare convulsive and subconvulsive effect in old and young mice, to evaluate the differences between ichthyogenesis and epileptogenesis.Rapid kindling model was performed using pentylenetetrazole in C57BL/6 mice. Using convulsive doses (C) (75 mg/kg in one injection) and sub-convulsive (SC) (10 mg/kg every 5 minutes for 30 minutes, for a total of 5 injections). Four groups were formed, young mouse (<32 weeks; C = 8; SC = 9) and 16 Old mouse (>32 weeks; C = 8; SC = 8). Using Racine Score. Descriptive statistics.Has been made 16 C protocols and 17 SC protocols. The latency time to phase 1 in sec. it is lower in old C (50.5 sec) than in young C (170.3). In SC, it was higher in the old group 170.3 vs young 105.5 (P = 0.001). Young C group presented longer time during Phase 1 to 3, and old C group during phase 4 and 5. Young SC presented longer duration in phase 2, unlike old SC with linear duration in different SR phases (P = 0.001). There were no differences in spontaneous death in all groups.Latency time to Phase 1 was shorter in old convulsives and longer than young SC, indicative greater ichthyogenesis and less epileptogenesis in the old population. Tendency in the elderly to stay longer in phases 4 and 5 in convulsive doses suggests a greater tendency to ichthyogenesis and greater severity of spontaneous seizures." @default.
• W2057216398 created "2016-06-24" @default.
• W2057216398 creator A5006198984 @default.
• W2057216398 creator A5046638013 @default.
• W2057216398 creator A5091560019 @default.
• W2057216398 date "1991-01-01" @default.
• W2057216398 modified "2023-10-04" @default.
• W2057216398 title "Functional anatomy of hippocampal seizures" @default.
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